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Filtering by: Academic Affiliation College of Veterinary Medicine Creator Häse, Claudia C.

Malonate Inhibits Virulence Gene Expression in Vibrio cholerae

Creator:

Minato, Yusuke, Fassio, Sara R., and Häse, Claudia C.

Abstract:

We previously found that inhibition of the TCA cycle, either through mutations or chemical inhibition, increased toxT transcription in Vibrio cholerae. In this study, we found that the addition of malonate, an inhibitor of succinate dehydrogenase (SDH), decreased toxT transcription in V. cholerae, an observation inconsistent with the previous pattern...

Resource Type:

Article
Sodium/Proton Antiporter Activity is Essential for Virulence of Yersinia pestis

Creator:

Faulkner, Wyatt J., Ghosh, Amit, Minato, Yusuke, Winogrodzki, Judith, Lind, Erin, Plano, Gregory V., Hinnebusch, Joseph B., Dibrov, Pavel, and Häse, Claudia C.

Abstract:

We found that a strains of Yersinia pestis (KIM5) which lacked the nhaA gene was fully attenuated in a plague model. This gene produces a protein of the sodium-proton antiporter family which expel sodium ions from the bacterial cytoplasm in exchange for hydrogen ions, or protons, from the surrounding environment....

Resource Type:

Poster