Index Catalog // ScholarsArchive@OSU

Creator:: Marley, Kevin, Helfand, Stuart C., Edris, Wade A., Mata, John E., Gitelman, Alix I., Medlock, Jan, and Seguin, Bernard
Abstract:: Background: Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6–12 months despite these treatments. Taurolidine, a derivative of taurine, has...
Resource Type:: Article
Full Text:: alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro Marley et al

Creator:: Marley, Kevin, Helfand, Stuart C., Simpson, Jennifer, Mata, John E., Tracewell, William G., Brownlee, Lisa, Bracha, Shay, and Séguin, Bernard
Abstract:: Background: Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidine has been shown to be cytotoxic to canine and human osteosarcoma in vitro....
Resource Type:: Article
Full Text:: for dogs with osteosarcoma Marley et al. Journal of Experimental & Clinical Cancer Research 2013, 32

Creator:: Harris, Krystal, L.
Abstract:: Background Bcl11b, previously CTIP2, is a zinc finger nuclear transcription factor involved in the development of keratinocytes, teeth, T lymphocytes, and nervous tissue. Expression of Bcl11b has been reported in human head and neck squamous cell carcinoma (HNSCC) and increased expression correlates with poorly differentiated tumors. This study aimed to...
Resource Type:: Masters Thesis
Full Text:: so for his friendship which will last a lifetime. I would also like to acknowledge Kevin Marley

Creator:: Lawrence, Yuri Alexander, 1980-
Abstract:: Blastocystis spp. is a common intestinal parasite in humans and animals that has been associated with acute or chronic digestive disorders such as irritable bowel syndrome. Serotonin mediates intestinal motility, sensation, and secretory function in the normal intestinal tract. Serotonin (5-HT) signaling is decreased in animal models of colitis, as...
Resource Type:: Masters Thesis
Full Text:: . Bernadette Stang, Ms. Cheri Goodall, and Dr. Kevin Marley for their technical assistance and expertise

Creator:: Westerman, Trina L.
Abstract:: Acute phase protein (APP) measurement can be used to characterize and rapidly detect inflammation. Serum amyloid A (SAA) and haptoglobin (HP) may be useful for diagnostic and prognostic purposes in horses presenting for colic and other inflammatory diseases. The objective of this thesis was to evaluate the use of SAA...
Resource Type:: Masters Thesis
Full Text:: express my thanks to Bernadette Stang, Cheri Goodall and Kevin Marley for their assistance in the

Creator:: Kinsley, Marc
Abstract:: The objective of this study was to elucidate the expression of signaling molecules associated with the Wnt signaling pathway in cartilage of prepubescent foals and determine their association with chondrocytes located at the osteochondral junction and cartilage canals. Our hypothesis was that increased expression of the components of the Wnt...
Resource Type:: Masters Thesis
Full Text:: Sciences University, and Kevin Marley for his technical assistance in the western blotting procedures

Creator:: Viall, Austin K.
Abstract:: The serotonergic system plays a significant regulatory role in osteoblast differentiation and proliferation. Serotonin (five-hydroxytryptamine or 5HT) may promote or inhibit osteoblast proliferation depending upon the serotonin receptor isoforms expressed by the cell. Classically, 5HT receptor 1B (5HTR1B) reduces osteoblast proliferation by inhibiting phosphorylation of the cAMP response element binding...
Resource Type:: Masters Thesis
Full Text:: , Kevin, and Pat – thank you all for the technical support, supply pillaging, and entertaining

ScholarsArchive@OSU