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Filtering by: Creator Jan Medlock Academic Affiliation College of Veterinary Medicine

A Multiplex Biomarker Approach for the Diagnosis of Transitional Cell Carcinoma from Canine Urine

Creator:

Bracha, Shay, McNamara, Michael, Hilgart, Ian, Milovancev, Milan, Medlock, Jan, Goodall, Cheri, Wickramasekara, Samanthi, and Maier, Claudia S.

Abstract:

Transitional cell carcinoma (TCC), the most common cancer of the urinary bladder in dogs, is usually diagnosed at an advanced disease stage with limited response to chemotherapy. Commercial screening tests lack specificity and current diagnostic procedures are invasive. A proof of concept pilot project for analyzing the canine urinary proteome...

Resource Type:

Article
The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro

Creator:

Marley, Kevin, Helfand, Stuart C., Edris, Wade A., Mata, John E., Gitelman, Alix I., Medlock, Jan, and Seguin, Bernard

Abstract:

Background: Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6–12 months despite these treatments. Taurolidine, a derivative of taurine, has...

Resource Type:

Article

Full Text:

osteosarcoma in vitro Kevin Marley1, Stuart C Helfand1, Wade A Edris1,4, John E Mata2, Alix I Gitelman3, Jan