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Filtering by: Creator Kuhl, Joseph C. Academic Affiliation College of Veterinary Medicine

Sodium/Proton Antiporter Activity is Essential for Virulence of Yersinia pestis

Creator:

Faulkner, Wyatt J., Ghosh, Amit, Minato, Yusuke, Winogrodzki, Judith, Lind, Erin, Plano, Gregory V., Hinnebusch, Joseph B., Dibrov, Pavel, and Häse, Claudia C.

Abstract:

We found that a strains of Yersinia pestis (KIM5) which lacked the nhaA gene was fully attenuated in a plague model. This gene produces a protein of the sodium-proton antiporter family which expel sodium ions from the bacterial cytoplasm in exchange for hydrogen ions, or protons, from the surrounding environment....

Resource Type:

Poster
Na +/H + Antiport Is Essential for Yersinia pestis Virulence

Creator:

Minato, Yusuke, Ghosh, Amit, Faulkner, Wyatt J., Lind, Erin J., Schesser Bartra, Sara, Plano, Gregory V., Jarrett, Clayton O., Hinnebusch, B. Joseph, Winogrodzki, Judith, Dibrov, Pavel, and Hase, Claudia C.

Abstract:

Na⁺/H⁺ antiporters are ubiquitous membrane proteins that play a central role in the ion homeostasis of cells. In this study, we examined the possible role of Na⁺/H⁺ antiport in Yersinia pestis virulence and found that Y. pestis strains lacking the major Na⁺/H⁺ antiporters, NhaA and NhaB, are completely attenuated in...

Resource Type:

Article

Full Text:

,c Clayton O. Jarrett,d B. Joseph Hinnebusch,d Judith Winogrodzki,e Pavel Dibrov,e Claudia C. Häsea