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Filtering by: Subject T cells Remove constraint Subject: T cells Academic Affiliation Environmental and Molecular Toxicology Remove constraint Academic Affiliation: Environmental and Molecular Toxicology Committee Member Leid, Mark Remove constraint Committee Member: Leid, Mark

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  • The influence of aryl hydrocarbon receptor activation on T cell fate

    Creator:
    Funatake, Castle J.
    Abstract:
    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
    Resource Type:
    Dissertation
    Full Text:
    Hydrocarbon Receptor Activation on T Cell Fate. approved: 2,3,7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) and

  • Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

    Creator:
    Rohlman, Diana
    Abstract:
    The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
    Resource Type:
    Dissertation
    Full Text:
    , may directly influence gene expression during CD4 + T-cell activation and differentiation, thereby