Index Catalog // ScholarsArchive@OSU

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: Abstract approved: _____________________________________________________________________ William M

In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

Creator:: Usenko, Crystal Y.
Abstract:: Due to their unique physical, chemical, and magnetic properties, nanomaterials have great potential for industrial development. There is a pressing need to develop rapid whole animal-based testing assays to assess the potential toxicity of engineered nanomaterials. To meet this challenge the embryonic zebrafish model was employed to determine the toxicity...
Resource Type:: Masters Thesis

Development and application of a new passive sampling device : the lipid-free tube (LFT) sampler

Creator:: Quarles, Lucas W.
Abstract:: Contaminants can exist in a wide range of states in aqueous environments, especially in surface waters. They can be freely dissolved or associated with dissolved or particulate organic matter depending on their chemical and physical characteristics. The freely dissolved fraction represents the most bioavailable fraction to an organism. These freely...
Resource Type:: Masters Thesis
Full Text:: Literature Cited 1. Schwarzenbach, R. P.; Gschwend, P. M.; Imboden, D. M., Environmental organic

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: , Koth CM, Buscher D, Kawakami Y, Itoh T, Raya RM, Sternik G, Tsai HJ, Rodriguez-Esteban C and Izpisua

Spatial and temporal variations of bioavailable polycyclic aromatic hydrocarbons in the lower Willamette River

Creator:: Sower, Gregory J.
Abstract:: Urban rivers with a history of industrial use can exhibit spatial and temporal variations in contaminant concentrations that may significantly affect risk evaluations and assessment of remediation efforts. To more effectively estimate human and ecological health risks, we evaluated the spatial and temporal distribution of polycyclic aromatic hydrocarbons (PAHs) in...
Resource Type:: Dissertation
Full Text:: .; Liem, D. A. K.; Steen, J. M. D.; Hutzinger, O., Relationship between bioconcentration in fish and

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Creator:: Choi, Jin-Young, 1964
Abstract:: Exposure to TCDD suppresses the generation of immune responses through unknown mechanisms. Interestingly, TCDD enhances inflammatory responses to various stimuli. The goal of the studies presented in this thesis was to examine the role of hyperinflammation in TCDD-induced immunotoxicity. Previously we observed an increase in Mac-1⁺ cells in the spleen...
Resource Type:: Dissertation
Full Text:: used to identify Mac-l + Cells in the spleen (A & B) and blood (C & D

Factors contributing to the formation of CC-->TT tandem mutations

Creator:: Skinner, Amy M.
Abstract:: The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
Resource Type:: Dissertation
Full Text:: chronic (24 hours) D-ala followed by UVC treatment……………………… 17. Mutational spectra induced by

New Applications for Passive Samplers : In-situ Flux and Risk Assessment of Legacy and Emerging Contaminants

Creator:: Tidwell, Lane G.
Abstract:: Passive sampling devices (PSDs) were used to measure air vapor and water dissolved phase concentrations of polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs) at two different environmentally contaminated sites. Environmental contaminates like PAHs and OPAHs are present in both the atmospheric and aqueous environmental compartments. It is known that...
Resource Type:: Dissertation

Exploring Silicone Wristbands as Personal Passive Sampling Devices in a Disaster Scenario

Creator:: Samon, Samantha M.
Abstract:: Exposure assessment is necessary to determine the frequency and magnitude of environmental contaminants, especially since exposure may lead to adverse health outcomes. Traditional personal exposure assessment tools such as biological samples are limited in their ability to capture a wide range of chemical exposures from a single sample, and others...
Resource Type:: Dissertation
Full Text:: . Carolyn M. Poutasse, Dr. Holly M. Dixon, Dr. Diana Rohlman, Dr. Peter D. Hoffman Ricky Scott and Mike

ScholarsArchive@OSU

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

Development and application of a new passive sampling device : the lipid-free tube (LFT) sampler

Unraveling tissue regeneration using chemical genetics

Spatial and temporal variations of bioavailable polycyclic aromatic hydrocarbons in the lower Willamette River

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Factors contributing to the formation of CC-->TT tandem mutations

New Applications for Passive Samplers : In-situ Flux and Risk Assessment of Legacy and Emerging Contaminants

Exploring Silicone Wristbands as Personal Passive Sampling Devices in a Disaster Scenario

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