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Filtering by: Academic Affiliation Environmental and Molecular Toxicology Creator Tanguay, Robert L. License Attribution 3.0 United States

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

Creator:

Miller, Galen W., Ulatowski, Lynn, Labut, Edwin M., Lebold, Katie M., Manor, Danny, Atkinson, Jeffrey, Barton, Carrie L., Tanguay, Robert L., and Traber, Maret G.

Abstract:

The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring...

Resource Type:

Article
The Aryl Hydrocarbon Receptor Mediates Leflunomide- Induced Growth Inhibition of Melanoma Cells

Creator:

O’Donnell, Edmond F., Kopparapu, Prasad Rao, Koch, Daniel C., Jang, Hyo Sang, Phillips, Jessica Lynne, Tanguay, Robert L., Kerkvliet, Nancy I., and Kolluri, Siva Kumar

Abstract:

A novel role of the dihydroorotatedehydrogenase (DHODH) inhibitor leflunomide as a potential anti-melanoma therapy was recently reported (Nature 471: 518-22, 2011). We previously reported that leflunomide strongly activates the transcriptional activity of the Aryl Hydrocarbon Receptor (AhR). We therefore tested whether the AhR regulates the anti-proliferative effects of leflunomide in...

Resource Type:

Article