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Filtering by: Creator Rodrigues, Ema G. Remove constraint Creator: Rodrigues, Ema G. Academic Affiliation Environmental and Molecular Toxicology Remove constraint Academic Affiliation: Environmental and Molecular Toxicology Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Creator:

Stanley, Kerri A.

Abstract:

The atmospheric transport and deposition of semi-volatile organic compounds (SOCs), including current and historic use pesticides, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), to mountain ecosystems may result in the exposure of tadpoles to these SOCs. This exposure has been implicated in amphibian population declines in California. Tadpoles encounter...

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Dissertation

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µg/L, corresponding to tissue EC50s of 367 ng/g and 4552 ng/g wet weight, respectively. However
A Multi-Tiered Approach Using Daphnia magna to Assess Chlorpyrifos Risk to Aquatic Receptors

Creator:

Maggio, Stephanie A.

Abstract:

Chlorpyrifos (CPF) is a widely used broad-spectrum organophosphate insecticide. Following exposures, CPF and its more toxic oxon metabolite (CPFO) elicit neurotoxic effects by inhibiting the activity of the acetylcholinesterase enzyme (AChE), resulting in altered fitness and death at high doses. Following exposure, organisms bioactivate CPF to CPFO through the Cytochrome...

Resource Type:

Dissertation

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lethal concentration (LC50) of 0.76 μg/L for CPF and 0.32 μg/L for CPFO, suggesting that CPFO is 2.4
Ligand selective regulation of cell growth by the Ah receptor through activation of TGF-beta signaling, Ligand selective regulation of cell growth by the Ah receptor through activation of TGFβ signaling

Creator:

Koch, Daniel C.

Abstract:

The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and member of the basic helix-loop-helix Per/ARNT/Sim (bHLH/PAS) family of chemosensors and developmental regulators. As a member of the PAS domain family of transcription factors responsive to exogenous signals, the AhR exerts influence on many processes relating to cellular fate....

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Dissertation

Full Text:

States of America 99(15): 9990-9995. Barretina, J., G. Caponigro, N. Stransky, K. Venkatesan, A. A
Investigations into the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression: effects on dendritic cell phenotype and function

Creator:

Vorderstrasse, Beth A.

Abstract:

T cell-dependent immune responses are highly sensitive to suppression by exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), yet direct effects of TCDD on T cells have been difficult to demonstrate. Because the activation of naive T cells is initiated by dendritic cells (DC), the studies presented in this dissertation were...

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Dissertation

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from a polymorphism in the ligand binding domain of the receptor (Ema et at., 1994). Although data
The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:

Funatake, Castle J.

Abstract:

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...

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Dissertation

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value in the range of 109M (Ema et al. 1994). Sources of HA H PCB were produced extensively in the US
Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Creator:

Saili, Katerine Schletz

Abstract:

Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...

Resource Type:

Dissertation

Full Text:

-hydroxyphenyl)propane; molecular weight = 228 g/mol; Figure 1-1) is a white powder that was first synthesized
Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:

Goodale, Britton C.

Abstract:

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...

Resource Type:

Dissertation
Unraveling tissue regeneration using chemical genetics

Creator:

Mathew, Lijoy K.

Abstract:

The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...

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Dissertation

Full Text:

. Development 129:2607-17. Poleo G, Brown CW, Laforest L and Akimenko MA (2001) Cell proliferation and
Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Creator:

Ruby, Carl E.

Abstract:

In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...

Resource Type:

Dissertation
Long-term fertilizer input influences total and bioavailable metal in agricultural soils and crops

Creator:

Pérez, Angela L.

Abstract:

Protection of the quality and integrity of food supplies is of global concern. Crops can accumulate non-nutritive and sometimes toxic metals and metalloids. Accumulated metals/metalloids can come in part, from fertilizers, which may contain variable levels of non-nutritive metals or metalloids such as arsenic (As), cadmium (Cd), lead (Pb), nickel...

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Dissertation

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metal concentration in the DGT device (CDGT), the following equation is used: CDGT=M∆g/(DtA) (1-2

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Academic Affiliation

Environmental and Molecular Toxicology[remove]15

Advisor

Curtis, Lawrence R.3
Tanguay, Robert L.3
Kerkvliet, Nancy I.2
Anderson, Kim A.1
Barofsky, Douglas F.1
more Advisors »

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 2001 to 2022

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Committee Member

Leid, Mark3
Anderson, Kim2
Buermeyer, Andrew2
Curtis, Larry2
Greenwood, Jeffrey2
more Committee Members »

Creator

Funatake, Castle J.1
Goodale, Britton C.1
Koch, Daniel C.1
Maggio, Stephanie A.1
Mathew, Lijoy K.1
more Creators »

Contributor

Janney, Philip K.1

Date

Date range begin – Date range end

Current results range from 2000 to 2021

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Decade

2020-20292
2010-20194
2000-20099

Degree Field

Toxicology15

Degree Level

Doctoral15

Degree Name

Doctor of Philosophy (Ph.D.)[remove]15

File Format

application/pdf1

Language

English [eng]15

License

All rights reserved12

Non-Academic Affiliation

Oregon State University. Graduate School13

Peer Reviewed

No15

Resource Type

Dissertation15

Rights Statement

In Copyright13
Copyright Not Evaluated2

Subject

DNA damage2
Dendritic cells2
Developmental toxicology2
Helix-loop-helix motifs2
Agricultural laborers -- Health and hygiene1
more Subjects »

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