Index Catalog // ScholarsArchive@OSU

Developmental axial skeletal deformities : baseline study with a zebrafish model

Creator:: Harden, Jon M.
Abstract:: The aim of this study was to assess sensitivity of early life stage zebrafish to cadmium (Cd). Embryos and larva were exposed to Cd before the formation of skeletal elements. Exposure times were selected to determine whether Cd perturbed developmental processes that lead to skeletal deformities, and to characterize the...
Resource Type:: Masters Thesis
Full Text:: . There was no effect of Cd on incidence of any type of skeletal deformity at 4Odpf(P>O.05 and p>O.O5

Alteration of cholesterol disposition by chlordecone is not explained by induction of cyp7a or cyp4a1

Creator:: Lee, JungA
Abstract:: Liver X receptor (LXR), farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR) are adopted orphan nuclear receptors that function as lipid sensors. These receptors respond to cellular lipid levels and regulate the expression of target gene. Previously, it was demonstrated that low doses of chlordecone (CD) pretreatment disturbed exogenous...
Resource Type:: Masters Thesis
Full Text:: ). There was no significant effect of CD treatment on liver-to-body weight ratio calculated as liver

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Creator:: Yu, Zhen
Abstract:: Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Resource Type:: Dissertation
Full Text:: 3-2 Effect of AHR genotype on mortality of offspring born to DBP-treated dams

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Creator:: Bravo, Claudia F.
Abstract:: During the past 30 years, numerous studies have focused on the toxicities of polycyclic aromatic hydrocarbons (PAH). Laboratory and field studies have helped elucidate the detrimental effects of these chemicals on growth, reproduction and immune response. Polycyclic aromatic hydrocarbons are in the priority list of chemicals to be studied by...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Toxicology presented on December 9. 2005. Title: Assessing Mechanisms

Environmental estrogens and skeletal development disruption in the fathead minnow : A teleost model of vertebrate developmental toxicity

Creator:: Warner, Kara E.
Abstract:: Natural and synthetic estrogenic compounds detected in surface waters have been linked to endocrine signaling disruption in several species. Endogenous estrogen contributes to cartilage and bone deposition during development in vertebrates, and is susceptible to perturbation from xenoestrogens. The goals of this work were to develop a teleost model to...
Resource Type:: Dissertation

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Creator:: Stanley, Kerri A.
Abstract:: The atmospheric transport and deposition of semi-volatile organic compounds (SOCs), including current and historic use pesticides, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), to mountain ecosystems may result in the exposure of tadpoles to these SOCs. This exposure has been implicated in amphibian population declines in California. Tadpoles encounter...
Resource Type:: Dissertation
Full Text:: responsible for most of the sediment sample preparation for chemical analysis for Chapter 3. Dr. Robert

Size and surface area dependent toxicity of silver nanoparticles in zebrafish embryos (Danio rerio)

Creator:: Tuttle, George R.
Abstract:: Many studies addressing the toxicity of silver nanomaterials have found that smaller sized silver nanoparticles are usually more toxic to organisms and in cell culture than particles of larger sizes yet it is not entirely clear why. We investigated the size dependent toxicity of silver nanoparticles by measuring the response...
Resource Type:: Masters Thesis
Full Text:: 3.3 Effect of the Chorion on Embryo Toxicity……………………………………………………... 21 TABLE

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Creator:: Norby, Tyler S.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are significant pollutants in aquatic environments. Many are carcinogenic and lead to DNA fragmentation and adduct formation in marine and freshwater organisms. Previous research demonstrates that rainbow trout (Oncorhynchus mykiss) compensate to long-term PAH dietary exposures and reduce the DNA damage. The aim of this study...
Resource Type:: Masters Thesis
Full Text:: previous research, there was no significant (P > 0.05) effect on body weight of the fish in any of the

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Toxicology presented on May 25, 2006. Title: Environmental Contaminants

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Creator:: Grove, Robert Allan
Abstract:: A large number of river otter (Lontra canadensis) males were collected from areas of high and low contaminant concentrations throughout western Oregon and Washington during the fall and winter of 1994-99. Few significant non-reproductive organ morphometric differences were found in the large series of male otters collected, except for adrenal...
Resource Type:: Dissertation
Full Text:: Page 39 Three dimensional graph showing the predicted effects of increasing 'PCB concentrations on

ScholarsArchive@OSU

Developmental axial skeletal deformities : baseline study with a zebrafish model

Alteration of cholesterol disposition by chlordecone is not explained by induction of cyp7a or cyp4a1

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Assessing mechanisms of immunotoxicity for polycyclic aromatic hydrocarbons in rainbow trout (Oncorhynchus mykiss)

Environmental estrogens and skeletal development disruption in the fathead minnow : A teleost model of vertebrate developmental toxicity

Semi-volatile organic compounds and developing organisms : accumulation in California mountain tadpoles in the field and fish embryo exposures in the laboratory

Size and surface area dependent toxicity of silver nanoparticles in zebrafish embryos (Danio rerio)

Antioxidant enzyme response in rainbow trout (Oncorhynchus mykiss) after subchronic exposure to an environmentally-relevant polycyclic aromatic hydrocarbon mixture

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

Environmental contaminants in male river otters collected from Oregon and Washington, 1994-99, with reproductive organ hypoplasia observed in otter males

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