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Filtering by: Creator Al-Hussinie, Abdulaziz S. Academic Affiliation Environmental and Molecular Toxicology

Disruptive chemicals, senescence and immortality

Creator:

Carnero, Amancio, Blanco-Aparicio, Carmen, Kondoh, Hiroshi, Lleonart, Matilde E., Martinez-Leal, Juan Fernando, Mondello, Chiara, Scovassi, A. Ivana, Bisson, William H., Amedei, Amedeo, Roy, Rabindra, Woodrick, Jordan, Colacci, Annamaria, Vaccari, Monica, Raju, Jayadev, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Salem, Hosni K., Memeo, Lorenzo, Forte, Stefano, Singh, Neetu, Hamid, Roslida A., Ryan, Elizabeth P., Brown, Dustin G., Wise, John P., Sr., Wise, Sandra S., and Yasaei, Hemad

Abstract:

Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...

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Article

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, Annamaria Colacci9, Monica Vaccari9, Jayadev Raju10, Fahd Al-Mulla11, Rabeah Al- Temaimi11, Hosni K. Salem12
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Creator:

Nahta, Rita, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Andrade-Vieira, Rafaela, Bay, Sarah N., Brown, Dustin G., Calaf, Gloria M., Castellino, Robert C., Cohen-Solal, Karine A., Colacci, Annamaria, Cruickshanks, Nichola, Dent, Paul, Di Fiore, Riccardo, Forte, Stefano, Goldberg, Gary S., Hamid, Roslida A., Krishnan, Harini, Laird, Dale W., Lasfar, Ahmed, Marignani, Paola A., Memeo, Lorenzo, Mondello, Chiara, Naus, Christian C., Ponce-Cusi, Richard, Raju, Jayadev, Roy, Debasish, Roy, Rabindra, Ryan, Elizabeth P., Salem, Hosni K., Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Vento, Renza, Vondráček, Jan, Wade, Mark, Woodrick, Jordan, and Bisson, William H.

Abstract:

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth...

Resource Type:

Article

Full Text:

Nahta, R., Al-Mulla, F., Al-Temaimi, R., Amedei , A., Andrade-Vieira, R., Bay, S. ... & Bisson, W. H

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Disruptive chemicals, senescence and immortality

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

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