Index Catalog // ScholarsArchive@OSU

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Lauren A. Courter

Passive sampling devices as biological surrogates for evaluating seasonal bioavailability of hydrophobic organic contaminants in surface water

Creator:: Sethajintanin, Doolalai
Abstract:: The seasonal distribution of bioavailable organochiorine contaminants in surface water and the potential environmental factors influencing their bioavailability were evaluated. The study was carried at the lower Willamette River at Portland Harbor, Oregon where surface water runoff varied according to season. Bioavailable water concentrations of DDTs and PCBs were determined...
Resource Type:: Dissertation
Full Text:: Contaminants in Surface Water. Abstract approved Kim A. Anderson The seasonal distribution of bioavailable

Developmental ramifications of dithiocarbamate pesticide exposure in zebrafish

Creator:: Tilton, Fred Anthony, 1973-
Abstract:: Dithiocarbamates are widely used agricultural pesticides, industrial chemicals and effluent additives. DTCs and their related compounds have historical and current relevance in clinical and experimental medicine. DTC developmental toxicity is well established, but poorly understood. Dithiocarbamates according to the U.S. EPA have a mechanism of action involving, "the inhibition of...
Resource Type:: Dissertation
Full Text:: toxicity is well established, but poorly understood. Dithiocarbamates according to the U.S. EPA have a

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

Creator:: Dearstyne, Erica A.
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Erica A. Dearstyne for the

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: activated antigen-specific T cells. A graft-versus-host (GVH) model, in which T cells from C57B1/6 (B6

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

Creator:: Smith-Roe, Stephanie L.
Abstract:: The DNA mismatch repair (MMR) pathway maintains genomic stability and reduces cancer risk (colorectal and other internal cancers) by correcting polymerase errors and activating cell cycle checkpoints and apoptosis in response to DNA damage. Few studies have examined the influence of commonly encountered environmental mutagens/carcinogens on the etiology of MMR-deficient...
Resource Type:: Dissertation
Full Text:: etiology of MMR-deficient cancers. 2-Amino-1-methyl-6- phenylimidazo [4,5-bJ pyridine (PhIP) is a cooked

Selenoprotein W : Purification and characterization of its interaction with calmodulin

Creator:: Bauman, Andrew Thomas
Abstract:: Selenoprotein W (SeW) is a protein whose function is unknown, but potentially plays a vital role in calcium metabolism, as an indirect link has been established with white muscle disease (WMD). White muscle disease occurs in selenium deficient animals, and is characterized by the precipitation of calcium in muscle, leading...
Resource Type:: Dissertation
Full Text:: out in rats fed a selenium enriched commercial chow. Western blot experiments showed SeW in the

Characterization of rodent selenoprotein W promoter

Creator:: Amantana, Adams
Abstract:: Rat selenoprotein W (SeW) promoter activity was investigated using different concentrations of cadmium, copper, and zinc. Two fragments (404bp and 1265bp) of the SeW promoter, containing a single metal response element (MRE), were ligated into the multiple cloning site of a pGL3-Basic reporter plasmid. The constructs were transfected into cultured...
Resource Type:: Dissertation
Full Text:: the SeW promoter, containing a single metal response element (MRE), were ligated into the multiple

Developmental axial skeletal deformities : baseline study with a zebrafish model

Creator:: Harden, Jon M.
Abstract:: The aim of this study was to assess sensitivity of early life stage zebrafish to cadmium (Cd). Embryos and larva were exposed to Cd before the formation of skeletal elements. Exposure times were selected to determine whether Cd perturbed developmental processes that lead to skeletal deformities, and to characterize the...
Resource Type:: Masters Thesis
Full Text:: Deformities: Baseline Study with a Zebrafish Model. Abstract approved Lawrence R. Curtis The aim of this

Metabolism of toxic plant alkaloids in livestock : comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model

Creator:: Duringer, Jennifer Marie
Abstract:: The pyrrolizidine alkaloids (PAs) and ergot alkaloids are known natural toxicants found in livestock forage. These alkaloids contribute to large economic losses in livestock throughout the world. An understanding of the mechanisms of toxicity and development of better diagnostic tools for better management practices was investigated. Variability exists in the...
Resource Type:: Dissertation
Full Text:: Alkaloids in Sheep and Cattle and of Ergot Alkaloids in an Endophyte-Resistant Mouse Model. Abstract a A

ScholarsArchive@OSU

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Passive sampling devices as biological surrogates for evaluating seasonal bioavailability of hydrophobic organic contaminants in surface water

Developmental ramifications of dithiocarbamate pesticide exposure in zebrafish

T lymphocyte death as a potential mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immune suppression

The influence of aryl hydrocarbon receptor activation on T cell fate

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

Selenoprotein W : Purification and characterization of its interaction with calmodulin

Characterization of rodent selenoprotein W promoter

Developmental axial skeletal deformities : baseline study with a zebrafish model

Metabolism of toxic plant alkaloids in livestock : comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model

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