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Filtering by: Committee Member Christopher, William Academic Affiliation Environmental and Molecular Toxicology

Involvement of inflammation and associated Mac-1⁺Gr-1⁺ cells in the immune suppression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Creator:

Choi, Jin-Young, 1964

Abstract:

Exposure to TCDD suppresses the generation of immune responses through unknown mechanisms. Interestingly, TCDD enhances inflammatory responses to various stimuli. The goal of the studies presented in this thesis was to examine the role of hyperinflammation in TCDD-induced immunotoxicity. Previously we observed an increase in Mac-1⁺ cells in the spleen...

Resource Type:

Dissertation

Full Text:

thank to my committee members: Dr. Christopher Bayne, Dr. Jerry Heidel, Dr David Williams, Dr. Olaf