Index Catalog // ScholarsArchive@OSU

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Creator:: Narayanan, Kannan Badri, Ali, Manaf, Barclay, Barry J., Bisson, William H., Cheng, Qiang, D'Abronzo, Leandro, Dornetshuber-Fleiss, Rita, Gosh, Paramita M., Gonalez-Guzman, Michael J., Lee, Tae-Jin, Leung, Po Sing, Li, Lin, Luanpitpong, Suidjit, Ratoviski, Edward, Rojanasakul, Yon, Romano, Maria Fiammetta, Romano, Simona, Sinha, Kumar Ranjeet, Yedjou, Clement, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G., Ryan, Elizabeth P., Colacci, Annamaria, Hamid, Roslida A., Mondello, Chiara, Raju, Jayadev, Salem, Hosni K., Woodrick, Jordan, Scovassi, Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Kim, Seo Yun, Lowe, Leroy, and Park, Hyun Ho
Abstract:: Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...
Resource Type:: Article
Full Text:: , Fort Collins, CO 80523-1680, USA, 18Center for Environmental Carcinogenesis and Risk Assessment

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Creator:: Saili, Katerine Schletz
Abstract:: Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
Resource Type:: Dissertation
Full Text:: applications for BPA-based polymers (Lee and Neville 1967). BPA is used in the manufacture of consumer

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:: Haggard, Derik
Abstract:: There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
Resource Type:: Dissertation
Full Text:: USEPA, two National Institutes of Health institutes, and the Food and Drug Administration (Collins et

Ligand selective regulation of cell growth by the Ah receptor through activation of TGF-beta signaling, Ligand selective regulation of cell growth by the Ah receptor through activation of TGFβ signaling

Creator:: Koch, Daniel C.
Abstract:: The Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and member of the basic helix-loop-helix Per/ARNT/Sim (bHLH/PAS) family of chemosensors and developmental regulators. As a member of the PAS domain family of transcription factors responsive to exogenous signals, the AhR exerts influence on many processes relating to cellular fate....
Resource Type:: Dissertation
Full Text:: . J. Fornace, K. S. Lee and F. J. Gonzalez (2000). "Altered cell cycle control at the G(2)/M phases

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: 1.2 (Collins et al., 1998; RI DEM, 2008; US EPA National Center for Environmental Assessment and

Biomarkers of oxidative stress and DNA damage in agricultural workers

Creator:: Muniz, Juan Fermin
Abstract:: Pesticides are among the most pervasive environmental contaminants and they are an important potential risk for human health. Agricultural workers are constantly exposed to pesticide spray, drift and residues in the soil and foliage. Many agricultural pesticides are readily absorbed by the body, through contact with the skin, the respiratory...
Resource Type:: Dissertation
Full Text:: for the detection of DNA damage (i.e., strand breaks and alkali labile sites) (Collins, 2004; Garaj

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation

Accumulation and effects of 4-nonylphenol in chinook salmon fry and their estuarine amphipod prey

Creator:: Hecht, Scott A.
Abstract:: 4-nonylphenol (NP), a surfactant degradation product, is an unregulated, ubiquitous aquatic contaminant and endocrine disruptor, for which aquatic life criteria are currently under development by U.S. EPA. The effects of NP on estuarine amphipods and chinook salmon fry were investigated, and this dissertation reports research into the impacts of NP...
Resource Type:: Dissertation
Full Text:: concentration (10 jig/L) was chosen because it is at the upper end of 25 environmental concentrations (Lee

Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

Creator:: Holden, Laura, L.
Abstract:: Since 2007, electronic cigarette (e-cigarette) sales in the U.S. have surpassed those of tobacco cigarettes. This is due, in part, to manufacturer’s claims that they are a safer alternative to tobacco cigarettes. However, formaldehyde, acrolein, and diacetyl have been detected in e-cigarettes and public knowledge of e-cigarette composition and potential...
Resource Type:: Masters Thesis

Nanotoxicology to Nanotherapeutics : Prioritizing Hazard and Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model

Creator:: Wehmas, Leah C.
Abstract:: The numerous different types of nanomaterials and paucity of reliable in vivo information on toxicity has resulted in enduring uncertainties associated with health and safety risks, thereby slowing progress in nanotherapeutic assessment and development. This dissertation explores how the embryonic zebrafish model can be applied to prioritize commonly used nanomaterial...
Resource Type:: Dissertation
Full Text:: ., 2007), they are now being applied to cancer imaging and therapeutics (Lee et al., 2007a; Lee et al

ScholarsArchive@OSU

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Developmental neurobehavioral toxicity of bisphenol A in zebrafish (Danio rerio)

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Ligand selective regulation of cell growth by the Ah receptor through activation of TGF-beta signaling, Ligand selective regulation of cell growth by the Ah receptor through activation of TGFβ signaling

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Biomarkers of oxidative stress and DNA damage in agricultural workers

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Accumulation and effects of 4-nonylphenol in chinook salmon fry and their estuarine amphipod prey

Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

Nanotoxicology to Nanotherapeutics : Prioritizing Hazard and Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model

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