Index Catalog // ScholarsArchive@OSU

Creator:: Larkin, Andrew, Siddens, Lisbeth K., Krueger, Sharon K., Tilton, Susan C., Waters, Katrina M., Williams, David E., and Baird, William M.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are present in the environment as complex mixtures with components that have diverse carcinogenic potencies and mostly unknown interactive effects. Non-additive PAH interactions have been observed in regulation of cytochrome P450 (CYP) gene expression in the CYP1 family. To better understand and predict biological effects of...
Resource Type:: Article
Full Text:: Andrew Larkin a,b,c, Lisbeth K. Siddens a,c, Sharon K. Krueger c,d, Susan C. Tilton c,e, Katrina M

Creator:: Crowell, Susan Ritger, Amin, Shantu G., Anderson, Kim A., Krishnegowda, Gowdahalli, Sharma, Arun K., Soelberg, Jolen J., Williams, David E., and Corley, Richard A.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants generated as byproducts of natural and anthropogenic combustion processes. Despite significant public health concern, physiologically based pharmacokinetic (PBPK) modeling efforts for PAHs have so far been limited to naphthalene, plus simpler PK models for pyrene, nitropyrene, and benzo[a]pyrene (B[a]P). The dearth of...
Resource Type:: Article
Full Text:: physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents Susan

Creator:: Siddens, Lisbeth K., Larkin, Andrew, Krueger, Sharon K., Bradfield, Christopher A., Waters, Katrina M., Tilton, Susan C., Pereira, Cliff B., Lohr, Christiane V., Arlt, Volker M., Phillips, David H., Williams, David E., and Baird, William M.
Abstract:: The polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), was compared to dibenzo[def,p]chrysene (DBC) and combinations of three environmental PAH mixtures (coal tar, diesel particulate and cigarette smoke condensate) using a two stage, FVB/N mouse skin tumor model. DBC (4 nmol) was most potent, reaching 100% tumor incidence with a shorter latency...
Resource Type:: Article
Full Text:: benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse Lisbeth K

Creator:: Cha, Jeeyeon, Burnum-Johnson, Kristin E., Bartos, Amanda, Li, Yingju, Baker, Erin S., Tilton, Susan C., Webb-Robertson, Bobbie-Jo M., Piehowski, Paul D., Monroe, Matthew E., Jegga, Anil G., Murata, Shigeo, Hirota, Yasushi, and Dey, Sudhansu K.
Abstract:: Embryonic diapause is a reproductive strategy widespread in the animal kingdom. This phenomenon is defined by a temporary arrest in blastocyst growth and metabolic activity within a quiescent uterus without implantation until the environmental and maternal milieu become favorable for pregnancy to progress. We found that uterine Msx expression persists...
Resource Type:: Article

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