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Filtering by: Creator Hahn, Linda Remove constraint Creator: Hahn, Linda Academic Affiliation Environmental and Molecular Toxicology Remove constraint Academic Affiliation: Environmental and Molecular Toxicology

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  • Investigations of the AhR-induced Treg : transcriptional regulation and suppressive mechanisms

    Creator:
    Rohlman, Diana
    Abstract:
    The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
    Resource Type:
    Dissertation
    Full Text:
    Linda B. Steppan Technical support; critical review of experimental design Zhen Yu Technical