Index Catalog // ScholarsArchive@OSU

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: : _________________________________________________________________ Staci L. Massey Simonich Robert L. Tanguay

Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

Creator:: Shankar, Prarthana
Abstract:: All animals have developed the critical ability to detect, respond to, and detoxify a large array of environmental chemicals and stressors that can cause adverse health effects. Important examples of landmark contaminants around the world are polycyclic aromatic hydrocarbons (PAHs) and dioxins, both of which can act via the aryl...
Resource Type:: Dissertation
Full Text:: Abstract approved: _____________________________________________________ Robyn L

Unraveling tissue regeneration using chemical genetics

Creator:: Mathew, Lijoy K.
Abstract:: The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Resource Type:: Dissertation
Full Text:: : Unraveling Tissue Regeneration Using Chemical Genetics. Abstract approved: Robert L

Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

Creator:: Holden, Laura, L.
Abstract:: Since 2007, electronic cigarette (e-cigarette) sales in the U.S. have surpassed those of tobacco cigarettes. This is due, in part, to manufacturer’s claims that they are a safer alternative to tobacco cigarettes. However, formaldehyde, acrolein, and diacetyl have been detected in e-cigarettes and public knowledge of e-cigarette composition and potential...
Resource Type:: Masters Thesis
Full Text:: approved: ______________________________________________________ Robert L. Tanguay Since 2007

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Creator:: Geier, Mitra Celestine
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
Resource Type:: Dissertation
Full Text:: Robert L. Tanguay Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants

Evaluating the Dietary Toxicity of Per- and Polyfluoroalkyl Substances and Development of a High Throughput Non-Invasive Zebrafish Cortisol Assay

Creator:: Leong, Connor A.
Abstract:: Per- and polyfluoroalkyl substances (PFAS) are contaminants of concern because they do not readily degrade in the environment. Some in vivo studies report that PFAS alter neurological development and are carcinogenic. Perfluorohexanesulfonamide (FHxSA) and 6:2 fluorotelomer sulfonate (6:2 FTS) are two PFASs, which are often detected in drinking water sources....
Resource Type:: Masters Thesis
Full Text:: Robyn L. Tanguay Per- and polyfluoroalkyl substances (PFAS) are contaminants of concern

Developing rapid in vivo assays to investigate structure response relationships

Creator:: Truong, Lisa
Abstract:: Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________________ Robert L. Tanguay Incorporation of nanoparticles (NPs) into consumer products is on the rise

Size and surface area dependent toxicity of silver nanoparticles in zebrafish embryos (Danio rerio)

Creator:: Tuttle, George R.
Abstract:: Many studies addressing the toxicity of silver nanomaterials have found that smaller sized silver nanoparticles are usually more toxic to organisms and in cell culture than particles of larger sizes yet it is not entirely clear why. We investigated the size dependent toxicity of silver nanoparticles by measuring the response...
Resource Type:: Masters Thesis
Full Text:: Nanoparticles in Zebrafish Embryos (Danio rerio) Abstract approved: Stacey L. Harper Many

‘Tis a Gift to be Simple : On Passive Sampling and Compatible Techniques for Reducing the Complexity of Environmental Mixtures

Creator:: Bergmann, Alan J.
Abstract:: Assessing the risk from exposure to a chemical mixture in the environment can seem prohibitively challenging. Most components of the mixture are not readily identifiable, chemicals may interact to cause other-than-additive toxicity, and the number of potential combinations of environmental contaminants is enormous. These challenges can make it seem impossible...
Resource Type:: Dissertation
Full Text:: , select sampling locations, and interpreting results. Robert L. Tanguay is the director of the

Nanotoxicology to Nanotherapeutics : Prioritizing Hazard and Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model

Creator:: Wehmas, Leah C.
Abstract:: The numerous different types of nanomaterials and paucity of reliable in vivo information on toxicity has resulted in enduring uncertainties associated with health and safety risks, thereby slowing progress in nanotherapeutic assessment and development. This dissertation explores how the embryonic zebrafish model can be applied to prioritize commonly used nanomaterial...
Resource Type:: Dissertation
Full Text:: Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model Abstract approved: Robert L

ScholarsArchive@OSU

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

Unraveling tissue regeneration using chemical genetics

Profiling Zebrafish Developmental Responses to E-Cigarette Flavor Mixtures

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Evaluating the Dietary Toxicity of Per- and Polyfluoroalkyl Substances and Development of a High Throughput Non-Invasive Zebrafish Cortisol Assay

Developing rapid in vivo assays to investigate structure response relationships

Size and surface area dependent toxicity of silver nanoparticles in zebrafish embryos (Danio rerio)

‘Tis a Gift to be Simple : On Passive Sampling and Compatible Techniques for Reducing the Complexity of Environmental Mixtures

Nanotoxicology to Nanotherapeutics : Prioritizing Hazard and Anticancer Efficacy of Nanomaterials using the Embryonic Zebrafish Model

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