Index Catalog // ScholarsArchive@OSU

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:: Chlebowski, Anna C.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
Resource Type:: Dissertation
Full Text:: and Tao, 2009). As a result of vehicular combustion, and increased use of biomass burning for heat

Xanthohumol, a flavonoid from hops (Humulus lupulus) : in vitro and in vivo metabolism, antioxidant properties of metabolites, and risk assessment in humans

Creator:: Yilmazer, Meltem
Abstract:: Reported here is an investigation to determine the in vitro and in vivo metabolism of xanthohumol (XN). XN is the major prenylated flavonoid of the female inflorescences (cones) of the hop plant (Humulus lupulus). It is also a constituent of beer, the major dietary source of prenylated flavonoids. Recent studies...
Resource Type:: Dissertation
Full Text:: rat liver microsomes. CO (carbon monoxide), SKF-525 (proadifen), ANF (x-naphthoflavone), TAO

Beyond the 16 EPA priority pollutant PAHs : environmental characterizations of oxygenated PAHs and dibenzopyrene isomers

Creator:: Layshock, Julie
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) with a molecular weight (MW) of 302 and oxygenated-PAHs (OPAHs) have demonstrated toxicity beyond that of frequently monitored and known carcinogenic PAHs. Airborne particulate matter (PM) was characterized for MW 302 isomers to evaluate risk and air quality indices and OPAHs in order to fill data...
Resource Type:: Dissertation
Full Text:: my other committee members, Dr. Larry Curtis and Dr. Dan Rockey. Thank you to Dr. Shu Tao and his

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Creator:: Geier, Mitra Celestine
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
Resource Type:: Dissertation
Full Text:: . However, their greatest overall environmental source is anthropogenic activity (Li et al. 2002; Zhang

Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse

Creator:: Siddens, Lisbeth K., Larkin, Andrew, Krueger, Sharon K., Bradfield, Christopher A., Waters, Katrina M., Tilton, Susan C., Pereira, Cliff B., Lohr, Christiane V., Arlt, Volker M., Phillips, David H., Williams, David E., and Baird, William M.
Abstract:: The polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), was compared to dibenzo[def,p]chrysene (DBC) and combinations of three environmental PAH mixtures (coal tar, diesel particulate and cigarette smoke condensate) using a two stage, FVB/N mouse skin tumor model. DBC (4 nmol) was most potent, reaching 100% tumor incidence with a shorter latency...
Resource Type:: Article

Metabolism of toxic plant alkaloids in livestock : comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model

Creator:: Duringer, Jennifer Marie
Abstract:: The pyrrolizidine alkaloids (PAs) and ergot alkaloids are known natural toxicants found in livestock forage. These alkaloids contribute to large economic losses in livestock throughout the world. An understanding of the mechanisms of toxicity and development of better diagnostic tools for better management practices was investigated. Variability exists in the...
Resource Type:: Dissertation

Per- and Polyfluoroalkyl Substances (PFAS): Protein Binding and Partitioning and Sorption in Light Non-Aqueous Phase Liquids

Creator:: Christie, Emerson C.
Abstract:: Per- and polyfluoroalkyl substances (PFAS) are anthropogenic surfactants that have recently been identified as persistent organic pollutants. These so called “Forever Chemicals” have been detected in drinking waters, ground waters, soils, and consumer and industrial products globally; with environmental impacts stretching into the artic, far from known PFAS sources. The...
Resource Type:: Dissertation
Full Text:: ), 486-493. 8. Liu, J.; Zhong, G.; Li, W.; Avendaño, S. M., Isomer-specific biotransformation of

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Creator:: Castro, David J.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a re-emerging class of environmental pollutants. The persistent nature of these highly toxic compounds along with their ubiquity in the environment creates an unavoidable route of exposure. The developing fetus and neonate are a particularly susceptible population due to their incomplete complement of xenobiotic metabolizing...
Resource Type:: Dissertation

Long-term fertilizer input influences total and bioavailable metal in agricultural soils and crops

Creator:: Pérez, Angela L.
Abstract:: Protection of the quality and integrity of food supplies is of global concern. Crops can accumulate non-nutritive and sometimes toxic metals and metalloids. Accumulated metals/metalloids can come in part, from fertilizers, which may contain variable levels of non-nutritive metals or metalloids such as arsenic (As), cadmium (Cd), lead (Pb), nickel...
Resource Type:: Dissertation

Adapting computer science technologies to bridge critical gaps in proposed Tox21 risk assessment programs

Creator:: Larkin, Andrew
Abstract:: In 2004 the National Toxicology Program published an article describing their intent to pursue toxicology testing and risk assessment practices solely reliant on high throughput in vitro datasets and in silico modeling for dose-response assessments. Support and contributions form regulatory agencies and a significant portion of the life sciences community...
Resource Type:: Dissertation
Full Text:: significantly larger than naturally occurring levels (Zhang and Tao, 2009). Benzo[a]pyrene (BaP) and dibenzo

ScholarsArchive@OSU

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Xanthohumol, a flavonoid from hops (Humulus lupulus) : in vitro and in vivo metabolism, antioxidant properties of metabolites, and risk assessment in humans

Beyond the 16 EPA priority pollutant PAHs : environmental characterizations of oxygenated PAHs and dibenzopyrene isomers

Classifying polycyclic aromatic hydrocarbon bioactivities using phenotypic screening and transcriptomics in the developmental zebrafish model

Polycyclic aromatic hydrocarbons as skin carcinogens: Comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse

Metabolism of toxic plant alkaloids in livestock : comparative studies on the hepatic metabolism of pyrrolizidine alkaloids in sheep and cattle and of ergot alkaloids in an endophyte-resistant mouse model

Per- and Polyfluoroalkyl Substances (PFAS): Protein Binding and Partitioning and Sorption in Light Non-Aqueous Phase Liquids

Critical windows of transplacental carcinogenesis : identifying efficacious approaches to chemoprevention with dietary phytochemicals

Long-term fertilizer input influences total and bioavailable metal in agricultural soils and crops

Adapting computer science technologies to bridge critical gaps in proposed Tox21 risk assessment programs

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