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Filtering by: Creator Vieira, Simon Academic Affiliation Environmental and Molecular Toxicology

Investigations into the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression: effects on dendritic cell phenotype and function

Creator:

Vorderstrasse, Beth A.

Abstract:

T cell-dependent immune responses are highly sensitive to suppression by exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), yet direct effects of TCDD on T cells have been difficult to demonstrate. Because the activation of naive T cells is initiated by dendritic cells (DC), the studies presented in this dissertation were...

Resource Type:

Dissertation
Per- and Polyfluoroalkyl Substances: From Disposition on Consumer Products and Field Materials to Treatment of Contaminated Groundwater

Creator:

Robel, Alix E.

Abstract:

Per- and polyfluoroalkyl substances (PFAS) are an emerging chemical class of concern. Recently in the United States, Health Advisory Limits for two PFAS in drinking water were established for perfluorooctane sulfonate and perfluorooctanoate in drinking water (set to 70 ng/L combine concentration) by the EPA. Because of PFAS mobility, persistence,...

Resource Type:

Dissertation
Elucidating the Signaling Events Downstream of Aryl Hydrocarbon Receptor Activation in Zebrafish

Creator:

Shankar, Prarthana

Abstract:

All animals have developed the critical ability to detect, respond to, and detoxify a large array of environmental chemicals and stressors that can cause adverse health effects. Important examples of landmark contaminants around the world are polycyclic aromatic hydrocarbons (PAHs) and dioxins, both of which can act via the aryl...

Resource Type:

Dissertation