Index Catalog // ScholarsArchive@OSU

Development of innovative applications for passive sampling devices : monitoring bioavailability, risk from exposure and environmental mixture toxicity

Creator:: Allan, Sarah E.
Abstract:: Chemicals must be bioavailable for there to be a potential for exposure and consequent risk to human or environmental health. Passive sampling devices (PSDs) are used to quantify the time-integrated concentration of bioavailable contaminants. We demonstrate that PSDs can be paired with the zebrafish developmental toxicity bioassay to produce site-specific,...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Sarah E. Allan for the degree of Doctor of Philosophy in

A Multi-Tiered Approach Using Daphnia magna to Assess Chlorpyrifos Risk to Aquatic Receptors

Creator:: Maggio, Stephanie A.
Abstract:: Chlorpyrifos (CPF) is a widely used broad-spectrum organophosphate insecticide. Following exposures, CPF and its more toxic oxon metabolite (CPFO) elicit neurotoxic effects by inhibiting the activity of the acetylcholinesterase enzyme (AChE), resulting in altered fitness and death at high doses. Following exposure, organisms bioactivate CPF to CPFO through the Cytochrome...
Resource Type:: Dissertation
Full Text:: , Sarah Rothenberg, Molly Kile, and Shelley Su, deserve a heartfelt thank you for their technical

Evaluating the Dietary Toxicity of Per- and Polyfluoroalkyl Substances and Development of a High Throughput Non-Invasive Zebrafish Cortisol Assay

Creator:: Leong, Connor A.
Abstract:: Per- and polyfluoroalkyl substances (PFAS) are contaminants of concern because they do not readily degrade in the environment. Some in vivo studies report that PFAS alter neurological development and are carcinogenic. Perfluorohexanesulfonamide (FHxSA) and 6:2 fluorotelomer sulfonate (6:2 FTS) are two PFASs, which are often detected in drinking water sources....
Resource Type:: Masters Thesis
Full Text:: . The fish were cut into sagittal sections and underwent hematoxylin and eosin (H&E) staining before

Purification and Characterization of Mouse Retinal Endothelial Cell Exosomes: Implications for Multi-Omics Analysis

Creator:: DePaepe, Anna
Abstract:: Metabolic defects within the different tissues and cell types of the eye give rise to many human ocular diseases. Polymorphisms in the Cytochrome P450 (CYP) family have been associated with many ocular disorders, particularly Cytochrome P450 1B1 (CYP1B1). Mutations in CYP1B1 have been linked to ocular diseases such as Primary...
Resource Type:: Masters Thesis

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Creator:: Yu, Zhen
Abstract:: Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...
Resource Type:: Dissertation
Full Text:: ,llpyrene in the B6 129 Mouse Model: Role of the Aryl Hydrocarbon Receptor Abstract David E. Williams

Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

Creator:: Yu, Zhen
Abstract:: The antimutagenic potency of wheat grain and berry extracts was studied in vitro against several heterocyclic amines (HCAs) using the Salmonella mutagenicity assay and the anticarcinogencity of wheat grain was studied in vivo using the rat colonic aberrant crypt focus assay. Wheat bran, which binds HCAs in vitro, as well...
Resource Type:: Masters Thesis
Full Text:: E. Williams The antimutagenic potency of wheat grain and berry extracts was studied in vitro

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Creator:: Leibelt, Dustin A.
Abstract:: Indole-3-carbinol (I3C) is a naturally occurring plant alkaloid, found in significant concentrations in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is an unstable compound that undergoes rapid oligomerization in an acidic environment to form higher order condensation products (I3C-ACPs), such as 3-3'-diindolylmethane (DIM). Both I3C and DIM are...
Resource Type:: Dissertation
Full Text:: , Chemoprevention and Human Health. Abstract David E. Williams Indole-3-carbinol (13 C) is a naturally occurring

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Creator:: Rosemond, Marie Victoire M.
Abstract:: Previous studies have shown that rainbow trout exposed to dieldrin via diet for 9 to 12 weeks increased biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500%. This was not explained by induction of the cytochrome P-450 (CYP) system involved in oxidative metabolism of these compounds. We hypothesized that...
Resource Type:: Masters Thesis
Full Text:: appreciation to the members of my graduate committee for their input and participation: Dr. David E. Williams

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Creator:: Lee, Junga
Abstract:: Overtly non-toxic doses of organochlorine (OC) insecticides perturb lipid homeostasis in mice and rats. To increase understanding of how chlordecone (CD), an OC insecticide, modulates cholesterol (CH) homeostasis, we determined the effect of CD pretreatment on the tissue and hepatic subcellular distribution of exogenous [¹⁴C]CH. Corn oil alone or CD...
Resource Type:: Dissertation
Full Text:: express sincere gratitude to Dr. David E. Williams for his expertise and encouragement in completing

Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

Creator:: Chang, Yvonne
Abstract:: The environmental health science community recognizes polycyclic aromatic hydrocarbons (PAHs) as a re-emerging class of environmental pollutants due to their persistence and prominence in mixtures of concern. Due to their widespread distribution in the environment, exposure to PAHs often occur as complex chemical mixtures. Exposures are linked to numerous adverse...
Resource Type:: Dissertation
Full Text:: . Environmental Protection Agency, Editor. 2010: Washington, DC 10 25. Gottmann, E., et al., Data

ScholarsArchive@OSU

Development of innovative applications for passive sampling devices : monitoring bioavailability, risk from exposure and environmental mixture toxicity

A Multi-Tiered Approach Using Daphnia magna to Assess Chlorpyrifos Risk to Aquatic Receptors

Evaluating the Dietary Toxicity of Per- and Polyfluoroalkyl Substances and Development of a High Throughput Non-Invasive Zebrafish Cortisol Assay

Purification and Characterization of Mouse Retinal Endothelial Cell Exosomes: Implications for Multi-Omics Analysis

Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by dibenzo[a,l]pyrene in the B6 129 mouse model : role of the Aryl Hydrocarbon Receptor

Antimutagenic potency of wheat grain and berry extracts in vitro and anticarcinogenicity of wheat grain in vivo

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Chlordecone (CD), a mixed steroid X receptor (SXR) and estrogen receptor alpha(ERα) agonist, altered hepatic cholesterol (CH) homeostasis and lipoprotein metabolism

Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

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