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Filtering by: Creator Zalom, Frank G. Academic Affiliation Environmental and Molecular Toxicology

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Creator:

Jiang, Changtao, Xie, Cen, Lv, Ying, Krausz, Kristopher W., Shi, Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., and Gonzalez, Frank J.

Abstract:

The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...

Resource Type:

Article