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  • Disease models and infectious phenotypes of Mycobacterium avium subspecies paratuberculosis

    Creator:
    Everman, Jamie L.
    Abstract:
    Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic inflammatory bowel disease that affects ruminant populations worldwide. The characteristic stages of the disease make diagnosis difficult, resulting in silent transmission among animals in a herd for years before proper detection of the infection. The extensive...
    Resource Type:
    Dissertation
    Full Text:
    . Many thanks go to the Department of Veterinary Medicine for technical advice and guidance on bovine

  • Biotransformation of 2,4,6-trinitrotoluene by ruminal organisms

    Creator:
    De Lorme, Marthah J. M.
    Abstract:
    2,4,6-Trinitrotoluene (TNT) has been the common munitions used in the world and is an environmental contaminant that is amendable to reductive transformation reactions. The rumen is an extremely reductive environment containing diverse microbial populations. There are 21 pure culture ruminal bacteria species in culture collection, these were tested for the...
    Resource Type:
    Dissertation
    Full Text:
    ability and one organism was completely inhibited by TNT concentrations of 100 mg/l. Of the 12 strains

  • The role of Salmonella typhimurium type three secretion system (T3SS) and effector proteins in chromatophore cell response.

    Creator:
    Farhad, Mohammad
    Abstract:
    Bacterial contamination of food poses a great risk to human health worldwide. A chromatophore cell-based biosensor, utilizing B. splendens erythrophore cells, is an emerging technology that has shown potential to detect bacterial toxicity based on function-dependent mechanisms. Previous studies have investigated the response of erythrophore cells to foodborne pathogens, pesticides,...
    Resource Type:
    Masters Thesis
    Full Text:
    May 21, 2013. Title: The Role of Salmonella typhimurium Type Three Secretion System (T3SS) and

  • Consequences of Influenza A Virus on Pneumococcal Biofilm Formation and Stability in the Absence of Host Factors

    Creator:
    Nutter, Laura
    Abstract:
    Streptococcus pneumoniae and Influenza A Virus both primarily infect the upper respiratory tract, with more severe disease occurring during coinfection than would be caused by either pathogen independently. Until recently, characterization of the interactions between these two pathogens has occurred exclusively in the context of a host or using host-derived...
    Resource Type:
    Masters Thesis
    Full Text:
    : Consequences of Influenza A Virus on Pneumococcal Biofilm Formation and Stability in the Absence of Host

  • Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

    Creator:
    Joseph, Jayanthi J.
    Abstract:
    To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...
    Resource Type:
    Dissertation
    Full Text:
    infection activates pro- inflammatory and anti-inflammatory pathways in macrophages. The balance of pro

  • Characterization of microaggregate formation by Mycobacterium avium subspecies hominissuis

    Creator:
    Babrak, Lmar
    Abstract:
    Mycobacterium avium subsp hominissuis (MAH) is an opportunistic environmental pathogen that causes respiratory and gastrointestinal illness in immunocompromised persons such as those with chronic respiratory diseases or AIDs, respectively. In recent years, there has been a significant increase in the incidence of nontuberculous mycobacterial (NTM) lung infections, including in cystic...
    Resource Type:
    Dissertation
    Full Text:
    protein enhanced the ability of microaggregates to invade HEp-2 cells, and exposure to anti-MIP-1 immune

  • Chromatophores as cell-based biosensors for the detection of chemically and biologically toxic substances

    Creator:
    Dukovcic, Stephanie R.
    Abstract:
    Cell-based biosensors are function-based detectors that use the physiological response of a living cell to sense biologically stimulating agents. This emerging technology extends the application of current detection methods by reporting on the toxicity of a sample and the potential to cause disease. Previously, Betta splendens erythrophores have been described...
    Resource Type:
    Dissertation
    Full Text:
    for the Detection of Chemically and Biologically Toxic Substances Abstract approved: Janine

  • Impacts of multispecies parasitism on coho salmon (Oncorhynchus kisutch) in Oregon

    Creator:
    Ferguson, Jayde A.
    Abstract:
    Diseases caused by parasites are recognized as significant sources of mortality in wild fish populations. I assessed the impacts of multispecies parasitism on a threatened stock of juvenile coho salmon (Oncorhynchus kisutch). A crucial prerequisite to this research was proper identification of parasites, which can be difficult for species lacking...
    Resource Type:
    Dissertation
    Full Text:
    and retrospective approaches. Results indicated that up to 95% of parr from the lower mainstem of

  • Investigating Vibrio parahaemolyticus interactions with the Pacific oyster, Crassostrea gigas

    Creator:
    Aagesen, Alisha M.
    Abstract:
    Vibrio parahaemolyticus is a Gram-negative, halophilic, human pathogenic bacterium ubiquitous in the marine environment. Like many Vibrio species, V. parahaemolyticus commonly associates with shellfish, particularly oysters. Ingestion of a raw or under cooked oysters contaminated with V. parahaemolyticus can cause gastroenteritis, which is typically self-limiting and rarely causes death. Globally,...
    Resource Type:
    Dissertation
    Full Text:
    investigations into the allelic diversity of MSHA and PilA from Vibrio cholerae and Vibrio vulnificus and found