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Filtering by: Creator Vega, Fernando E. Academic Affiliation Microbiology Creator Emelyanov, Alexander Language English [eng]

An inducible kras[superscript v]¹² transgenic zebrafish model for liver tumorigenesis and chemical drug screening

Creator:

Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Parinov, Serguei, and Gong, Zhiyuan

Abstract:

Because Ras signaling is frequently activated by major hepatocellular carcinoma etiological factors, a transgenic zebrafish constitutively expressing the kras(V12) oncogene in the liver was previously generated by our laboratory. Although this model depicted and uncovered the conservation between zebrafish and human liver tumorigenesis, the low tumor incidence and early mortality...

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Article

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Zhiyuan Gong1,‡ RESEARCH ARTICLE D ise as e M od el s & M ec ha ni sm s D M M
A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

Creator:

Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Lam, Siew Hong, Mathavan, Sinnakaruppan, Parinov, Serguei, and Gong, Zhiyuan

Abstract:

Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma (HCC) being the most common type. Aberrant Ras signaling has been implicated in the development and progression of human HCC, but a complete understanding of the molecular mechanisms of this protein in hepatocarcinogenesis remains elusive. In this...

Resource Type:

Article

Full Text:

Zhiyuan Gong1,* RESEARCH ARTICLE D ise as e M od el s & M ec ha ni sm s D M M

ScholarsArchive@OSU

An inducible kras[superscript v]¹² transgenic zebrafish model for liver tumorigenesis and chemical drug screening

A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

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