Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Academic Affiliation Microbiology Creator Freitag, Michael Rights Statement Copyright Not Evaluated

Bacterial Resistance to Antisense Peptide-Phosphorodiamidate Morpholino Oligomers

Creator:

Puckett, Susan E., Reese, Kaleb A., Mitev, Georgi M., Mullen, Valerie, Johnson, Rudd C., Pomraning, Kyle R., Mellbye, Brett L., Tilley, Lucas D., Iversen, Patrick L., Freitag, Michael, and Geller, Bruce L.

Abstract:

Peptide phosphorodiamidate morpholino oligomers (PPMO) are synthetic DNA mimics that bind complementary RNA and inhibit bacterial gene expression. (RFF)₃RXB- AcpP PPMO (R, arginine; F, phenylalanine; X, 6-aminohexanoic acid; B, β-alanine) is complementary to 11 bases of the essential gene acpP (encodes acyl carrier protein). The MIC of (RFF)₃RXB-AcpP was 2.5...

Resource Type:

Article