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Filtering by: Creator Nguyen, Thi Kim Anh Academic Affiliation Microbiology Creator Gong, Zhiyuan

An inducible kras[superscript v]¹² transgenic zebrafish model for liver tumorigenesis and chemical drug screening

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Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Parinov, Serguei, and Gong, Zhiyuan

Abstract:

Because Ras signaling is frequently activated by major hepatocellular carcinoma etiological factors, a transgenic zebrafish constitutively expressing the kras(V12) oncogene in the liver was previously generated by our laboratory. Although this model depicted and uncovered the conservation between zebrafish and human liver tumorigenesis, the low tumor incidence and early mortality...

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promoter (Nguyen et al., 2011). Although this model has revealed several molecular mechanisms underlying
A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

Creator:

Nguyen, Anh Tuan, Emelyanov, Alexander, Koh, Chor Hui Vivien, Spitsbergen, Jan M., Lam, Siew Hong, Mathavan, Sinnakaruppan, Parinov, Serguei, and Gong, Zhiyuan

Abstract:

Human liver cancer is one of the deadliest cancers worldwide, with hepatocellular carcinoma (HCC) being the most common type. Aberrant Ras signaling has been implicated in the development and progression of human HCC, but a complete understanding of the molecular mechanisms of this protein in hepatocarcinogenesis remains elusive. In this...

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robust liver tumorigenesis in transgenic zebrafish Anh Tuan Nguyen1,2, Alexander Emelyanov2, Chor Hui

ScholarsArchive@OSU

An inducible kras[superscript v]¹² transgenic zebrafish model for liver tumorigenesis and chemical drug screening

A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish

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