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Filtering by: Creator Thomas, Dennis Remove constraint Creator: Thomas, Dennis Academic Affiliation Microbiology Remove constraint Academic Affiliation: Microbiology File Format application/pdf Remove constraint File Format: application/pdf

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  • Characterization of vaccinia virus A12L protein : its proteolysis and functional analyses in virus replication

    Creator:
    Yang, Su Jung
    Abstract:
    In order to produce infectious virus progeny, vaccinia virus (VV) undergoes morphogenic proteolysis to regulate the structural rearrangements of virus particles. Several of the major structural precursor proteins of VV are cleaved at a conserved Ala-Gly-X (where X is any amino acid) motif by the VV I7L core protein proteinase...
    Resource Type:
    Dissertation
    Full Text:
    : Dr. Dennis E. Hruby In order to produce infectious virus progeny, vaccinia virus (VV

  • Structure-function analysis of the vaccinia virus I7L proteinase

    Creator:
    Moerdyk, Megan J.
    Abstract:
    Vaccinia virus is the prototypic member of the Orthopoxvirus genus. It undergoes a complex replication process where a key step in the transition from immature virion to intracellular mature virion is the cleavage of the major core protein precursors. The product of the I7L open reading frame (ORF) is a...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: ______________________________________________________________ Dennis E. Hruby

  • Developing a system of mutagenesis in Francisella tularensis LVS

    Creator:
    Flax, Lindsay A.
    Abstract:
    Francisella tularensis is a gram-negative facultative intracellular coccobacillus that primarily infects macrophages. The causative agent of tularemia, this bacterium is considered among the most infectious organisms known, requiring fewer than ten organisms to cause disease. Although ubiquitous in nature, transmission to humans is rare but can occur via insect bites,...
    Resource Type:
    Masters Thesis

  • Analysis of chlamydial and host proteins associated with infection

    Creator:
    Chu, Hencelyn
    Abstract:
    Chlamydiae are obligate intracellular bacteria that infect a variety of eukaryotic hosts and affect normal host processes. Within host cells, their developmental cycle takes place inside non-acidified vacuoles termed inclusions. An inclusion membrane composed primarily of secreted chlamydial synthesized proteins called Incs encloses the inclusion. At this location, Incs have...
    Resource Type:
    Dissertation