Index Catalog // ScholarsArchive@OSU

Single-Cell Genomics of Uncultivated Marine Bacteria

Creator:: Landry, Zachary
Abstract:: Historically, the difficulty of obtaining pure cultures of abundant marine microbial plankton has an obstacle to reconstructing the underlying mechanisms of biogeochemistry in the ocean. While a number of dominant marine species from the ocean surface have been cultured, the dominant microbial plankton of the dark ocean proved far more...
Resource Type:: Dissertation
Full Text:: Single-copy gene cluster conservation as a function of the number of Chloroflexi genomes, and fitted

Preventing crown gall disease using oncogene silencing or VirE1-expressing transgenics

Creator:: Humann, Jodi L.
Abstract:: Crown gall disease is caused by the ubiquitous soil bacterium Agrobacterium tumefaciens which transfers a portion if DNA (T-DNA) into the plant cell. Preventing infection by using the biocontrol strain Agrobacterium radiobacter K84 is currently the only defense for crown gall. Two different resistance strategies were examined in this work....
Resource Type:: Dissertation
Full Text:: resistance strategy examined in this work is gene silencing of the A. tumefaciens oncogenes iaaM and ipt

Toxigenic and non-toxigenic strains of Clostridium botulinum type E : A. Differentiation by immunodiffusion : B. Attempts to induce toxigenicity by mutagenic agents

Creator:: Balstraz, Edwina Gene
Abstract:: In this study of toxigenic and non-toxigenic strains of Clostridium botulinum type E, attempts were made to induce toxin production in non-toxigenic cultures by exposure to mutagenic agents and to differentiate the organisms by immunodiffusion. First, cultures of non-toxic Cl. botulinum type E were exposed to various mutagenic agents in...
Resource Type:: Masters Thesis
Full Text:: agents AN ABSTRACT OF THE THESIS OF EDWINA GENE BALSTRAZ for the (Name of student) in Microbiology

Characterizing the Accuracy of Phylogenetic Analyses that Leverage 16S rRNA Sequencing Data

Creator:: Humphreys, Ian R.
Abstract:: Investigations of 16S rRNA gene sequences hallmark modern microbiology. These sequences provide culture-independent insight into the abundance and distribution of microbiota and serve as a principle resource through which microbial community diversity is measured. Consequently, researchers rely on 16S gene sequences to test hypotheses rooted in ecology, evolution, and disease....
Resource Type:: Masters Thesis
Full Text:: . Abstract approved: ______________________________________________________ Thomas J. Sharpton

Characterization of Baculovirus genes involved in genome replication and processing

Creator:: Vanarsdall, Adam L.
Abstract:: The Baculoviridae comprise a diverse group of occluded DNA viruses that contain large double-stranded DNA genomes of 80 - 180 kb and may encode up to 180 gene products. To understand how baculoviruses replicate and process their genomes and the gene products that are involved in these events, a series...
Resource Type:: Dissertation
Full Text:: that contain large double-stranded DNA genomes of 80 - 180 kb and may encode up to 180 gene

Host-pathogen Interactions of Respiratory RNA Viruses and the Application of Recombinase Polymerase Amplification for Viral Diagnostics

Creator:: Prescott, Meagan A.
Abstract:: Humans and viral disease are inextricably intertwined. Viral disease plays an immeasurable role in human life, from the disease and economic burden associated with every facet of contending with human viral disease, to managing the consequences of viral disease in organisms important to our food supply, economy, and entertainment. The...
Resource Type:: Dissertation
Full Text:: purposes. PPMO antisense technology was employed to target and suppress the expression of the host gene

Physiological, biochemical, and genetic studies on the [delta]²⁴ sterol methyltransferase of Saccharomyces cerevisiae

Creator:: McCammon, Mark Thomas
Abstract:: The role of the yeast S-adenosylmethionine: Δ²⁴-sterol-C-methyltransferase (SCMT) in sterol metabolism was investigated. Structural analogs of S-adenosylhomocysteine were tested for inhibition of the SCMT enzyme. A wide inhibitory range by these compounds was observed, indicating which structural features of the parent compound are important for binding to the enzyme. The...
Resource Type:: Dissertation
Full Text:: Thomas McCammon for the degree of Doctor of Philosophy in Microbiology presented on December 14, 1982

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula

Creator:: Ramaswamy, Aishwarya V.
Abstract:: Cyanobacteria are rich in biologically active secondary metabolites, many of which have potential application as anticancer or antimicrobial drugs or as useful probes in cell biology studies. A Jamaican isolate of the marine cyanobacterium, Lyngbya majuscula was the source of a novel antifungal and cytotoxic secondary metabolite, hectochlorin. The structure...
Resource Type:: Dissertation
Full Text:: Biochemical Characterization of the Hectochiorin Biosynthetic Gene Cluster from the Marine Cyanobacterium

The regulation of a vaccinia virus late gene required for morphogenesis

Creator:: Miner, Jeffery N.
Abstract:: Vaccinia virus gene expression is characterized by tight temporal regulation. Viral early transcription begins within the cytoplasm upon infection; three hours later, early genes are repressed, DNA replication occurs and late gene expression commences. As an approach toward understanding the mechanisms governing vaccinia late gene expression, I have undertaken an...
Resource Type:: Dissertation
Full Text:: The regulation of a vaccinia virus late gene required for

Molecular genetic analysis of vaccinia virus genes which confer resistance to alpha-amanitin

Creator:: Tamin, Azaibi
Abstract:: Several laboratories have shown that the VV replication cycle is dependent on the host cell nucleus. The basic biological observation is that if the host cell nucleus is physically removed by cytochalasin B-mediated enucleation, functionally inactivated by UV-irradiation, or selectively blocked with a-amanitin, the results are the same: W is...
Resource Type:: Dissertation
Full Text:: of this virus- host cell interaction, one approach is to identify the viral gene(s) responsible for

ScholarsArchive@OSU

Single-Cell Genomics of Uncultivated Marine Bacteria

Preventing crown gall disease using oncogene silencing or VirE1-expressing transgenics

Toxigenic and non-toxigenic strains of Clostridium botulinum type E : A. Differentiation by immunodiffusion : B. Attempts to induce toxigenicity by mutagenic agents

Characterizing the Accuracy of Phylogenetic Analyses that Leverage 16S rRNA Sequencing Data

Characterization of Baculovirus genes involved in genome replication and processing

Host-pathogen Interactions of Respiratory RNA Viruses and the Application of Recombinase Polymerase Amplification for Viral Diagnostics

Physiological, biochemical, and genetic studies on the [delta]²⁴ sterol methyltransferase of Saccharomyces cerevisiae

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula

The regulation of a vaccinia virus late gene required for morphogenesis

Molecular genetic analysis of vaccinia virus genes which confer resistance to alpha-amanitin

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