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Filtering by: Academic Affiliation Public Health Creator Houseman, E. Andres

Differential DNA Methylation in Umbilical Cord Blood of Infants Exposed to Low Levels of Arsenic in Utero

Creator:

Koestler, Devin C., Avissar-Whiting, Michele, Houseman, E. Andres, Karagas, Margaret R., and Marsit, Carmen J.

Abstract:

Background: There is increasing epidemiologic evidence that arsenic exposure in utero, even at low levels found throughout much of the world, is associated with adverse reproductive outcomes and may contribute to long-term health effects. Animal models, in vitro studies, and human cancer data suggest that arsenic may induce epigenetic alterations,...

Resource Type:

Article
Recursively partitioned mixture model clustering of DNA methylation data using biologically informed correlation structures

Creator:

Koestler, Devin C., Christensen, Brock C., Marsit, Carmen J., Kelsey, Karl T., and Houseman, E. Andres

Abstract:

DNA methylation is a well-recognized epigenetic mechanism that has been the subject of a growing body of literature typically focused on the identification and study of profiles of DNA methylation and their association with human diseases and exposures. In recent years, a number of unsupervised clustering algorithms, both parametric and...

Resource Type:

Article