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Filtering by: DOI 10.1172/JCI62070 Academic Affiliation School of Biological and Population Health Sciences

Regulation of Skeletal Muscle Insulin Action and Fatty Acid Trafficking with Obesity and Exercise

Creator:

Stierwalt, Harrison D.

Abstract:

Altered skeletal muscle fat metabolism is linked to changes in skeletal muscle insulin sensitivity. Whereby the accumulation of bioactive signaling lipids (i.e., diacylglycerols and ceramides) within skeletal muscle are negatively associated with insulin sensitivity and the exercise-induced changes to fatty acid trafficking are related to improved skeletal muscle insulin action....

Resource Type:

Dissertation
The Roles of Dietary Nitrate in Bone and the Gut in an Ovarian Hormone-deficient Rodent Model

Creator:

Conley, Melissa N.

Abstract:

Osteoporosis is a common metabolic bone disease, affecting a third of women and a fifth of men over age 65. In the US, annual health care costs associated with osteoporosis are estimated to be over $20 billion. Osteoporosis is associated with increased fracture risk, which has been demonstrated to predict...

Resource Type:

Dissertation
The Relationship Between IGF-1 and Bone Turnover in a Non-Human Primate Model of Voluntary Alcohol Consumption

Creator:

Sattgast, Lara H.

Abstract:

Alcohol is a widely consumed, nonessential, bioactive nutrient with end-organ effects on the skeleton. Moderate levels of alcohol consumption are generally associated with increased bone mineral density (BMD), whereas higher intake levels result in reduced bone formation, bone loss, and increased risk for osteoporotic fracture. Given the negative impact of...

Resource Type:

Dissertation