Index Catalog // ScholarsArchive@OSU

Creator:: Salih, M. Quamar
Abstract:: Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
Resource Type:: Dissertation
Full Text:: .! Tetrahedron,Lett.!1995,!36,!75.! 4!Mazzocchi,! P.! H.;! Ammon,! H.! L.;! Liu,! L.;! Colicelli,! E.;! Ravi,! P

Creator:: Overacker, Ross D.
Abstract:: Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Resource Type:: Dissertation
Full Text:: level inhibition (∼7 µM) of HIV-1 by acting on the RNase H activity of the viral reverse transcriptase

Creator:: Points, Gary L., III
Abstract:: Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
Resource Type:: Dissertation
Full Text:: . Using this strategy, many 4-substituted indolines and indoles were readily prepared from 3-amino-2

Creator:: Juniku, Rajan B.
Abstract:: Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...
Resource Type:: Dissertation
Full Text:: (Fig 4).2 Me3N O O Acetylcholine (1) HO HO NH2 HO HO (R) NH2 OH HO N H NH2 Dopamine (5

Creator:: Schwartz, Keith D.
Abstract:: Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
Resource Type:: Dissertation
Full Text:: phomactin B2 4 O O OH H α -OH; phomactin B 2 β- OH; phomactin B1 3 O O OH H HO H O O H CHO

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation
Full Text:: steps 12: R = Bn 13: R = H H2, Pd/C, EtOH 25 ºC 100% TPAP, NMO, 4 A MS DCM, 25 ºC O O O PivO O P

Creator:: Kaweesa, Elizabeth Namagoba
Abstract:: Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell...
Resource Type:: Masters Thesis
Full Text:: ............................................4 Section 1.3 Summary of initial mensacarcin mode of action studies

ScholarsArchive@OSU