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Filtering by: Committee Member Christensen, John M. Advisor Alani, Adam W. G.

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Creator:

Doddapaneni, Bhuvana S.

Abstract:

Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...

Resource Type:

Dissertation

Full Text:

my committee members Dr Oleh Taratula, Dr Mark Christensen, Dr Arup Indra and Dr Julie Greenwood
Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

Creator:

Cote, Brianna M.

Abstract:

Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...

Resource Type:

Dissertation

Full Text:

THE DISSERTATION OF Brianna M. Cote for the degree of Doctor of Philosophy in Pharmaceutical