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Filtering by: Advisor Ayres, James W. Committee Member Thomas, David Language English [eng] Rights Statement Copyright Not Evaluated

1. New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation

2. New acetaminophen products : formulation development and bioavailability

Creator:: Mansell, Libbie J.
Abstract:: Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
Resource Type:: Dissertation