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Filtering by: Creator Whitman, L. D. Remove constraint Creator: Whitman, L. D. Advisor Ayres, James W. Remove constraint Advisor: Ayres, James W. Committee Member Thomas, David Remove constraint Committee Member: Thomas, David Non-Academic Affiliation Oregon State University. Graduate School Remove constraint Non-Academic Affiliation: Oregon State University. Graduate School

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  • New acetaminophen products : formulation development and bioavailability

    Creator:
    Mansell, Libbie J.
    Abstract:
    Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
    Resource Type:
    Dissertation
    Full Text:
    Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores

  • New product formulation and multiple dose pharmacokinetics of acetaminophen

    Creator:
    Sahajwalla, Chandrahas G.
    Abstract:
    Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
    Resource Type:
    Dissertation
    Full Text:
    on statistically significant differences in elimination, half life, mean residence time and AUC/D