Index Catalog // ScholarsArchive@OSU

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Creator:: Ahmed, Iman Saad
Abstract:: This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
Resource Type:: Dissertation
Full Text:: University libraries. My signature below authorizes release of my thesis to any reader upon request Iman S

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Creator:: Watanalumlerd, Prapoch
Abstract:: Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
Resource Type:: Dissertation
Full Text:: profiles of riboflavin-S-phosphate from leaky enteric-coated pellet formulations (RF 1 to RF4

Bioadhesive polymers in drug product formulations

Creator:: Tavipatana, Wattanaporn
Abstract:: Gastric retention time of single unit dosage forms in swine was found to be much longer than in humans. It was concluded that swine are not a good animal model to study GI transit time of nonerodable or slowly eroded dosage forms. Noneradable and slowly eroded dosage forms used to...
Resource Type:: Dissertation
Full Text:: 350 ml of buffer solution pH 1.4 (a), 5.5 (s) and 7.2 (U). 65 Figure 11.6 Dynamic swelling of 500 mg

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Creator:: Hossain, Mohammad
Abstract:: Gastrointestinal (GI) transit data were collected using pigs as animal models. Density and size effects of non-disintegrating dosage forms on GI transit were investigated. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate...
Resource Type:: Dissertation
Full Text:: . 53, 145-155 (1989). 43. Davis S.S., Parr G.D., Feely L., Leslie S.T., Malkowska S., and Lockwood G.F

Calcium alginate gels in oral dosage form design

Creator:: Lin, Shun Yih
Abstract:: In vivo research following ingesting of commercially available Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose of four tablets daily, showed serum lipoprotein concentrations did not change significantly. In order to increase the number of viable Lactobacillus bacteria after challenging in...
Resource Type:: Dissertation
Full Text:: ml deionized water and mixed for about 30 s; then 1 ml was mixed with 4 ml deionized water. One ml

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Creator:: Farid, Samar Farghali
Abstract:: This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...
Resource Type:: Dissertation
Full Text:: parameters of HCTZ after oral administration of 50 mg JR tablets or GRF capsules to subject S in the fed

New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation
Full Text:: ., 1976; Davis et. al., 1976). A useful antidote for acetaminophen toxicity is N-acetylcysteine

Development and in vivo testing of a gastric retention device (GRD) in dogs

Creator:: Kapsi, Shivakumar G.
Abstract:: This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
Resource Type:: Dissertation
Full Text:: my friend Dr. S. N. Murthy for sparing his time and going through the proof meticulously. I thank

Formulation studies of lactic acid-producing bacteria for oral administration

Creator:: Liou, Yow-Hwa Grace
Abstract:: Effects of lactobacilli in enteric coated capsules were studied in piglets (Chapter I). Lactobacillus acidophilus and Lactobacillus bulgaricus isolated from a commercial product were formulated in capsules, enteric coated, and then given to both Escherichia coli-challenged and unchallenged baby pigs. Decreased incidence and severity of diarrhea, and decreased weight deceleration...
Resource Type:: Dissertation
Full Text:: calves (52,54,55). Researchers concluded that S. faecium reduced the toxic effects of E. coli, lowered

Development of Hot-melt Pan-coating, Application to Sustained-release Capsules and Tamper Resistant-coating. 2) Formulation of Verapamil HCl and Diltiazem HCl Semisolid Matrix Capsules. 3) Novel Sustained Release Tablet of Glipizide: Compression of Coated Drug Beads, Formulation, Dissolution, and Convolution. 4) Verapamil Sustained Release: New Formulation and Convolution

Creator:: Nguyen, Chien Ngoc
Abstract:: Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating...
Resource Type:: Dissertation

ScholarsArchive@OSU

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Bioadhesive polymers in drug product formulations

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Calcium alginate gels in oral dosage form design

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

New product formulation and multiple dose pharmacokinetics of acetaminophen

Development and in vivo testing of a gastric retention device (GRD) in dogs

Formulation studies of lactic acid-producing bacteria for oral administration

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