Index Catalog // ScholarsArchive@OSU

Pharmacokinetic/pharmacodynamic modeling/simulation and novel gastric retention formulation

Creator:: Kwon, Hyojong
Abstract:: This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
Resource Type:: Dissertation
Full Text:: major committee, Professor J. Mark Christensen and Professor Rosita J. Rodriguez for being untiring

New acetaminophen products : formulation development and bioavailability

Creator:: Mansell, Libbie J.
Abstract:: Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
Resource Type:: Dissertation
Full Text:: bioavailability AN ABSTRACT OF THE THESIS OF Libbie J. Mansell for the degree of Doctor of Philosophy in

Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors

Creator:: Fahmy, Sahar Abd El-Sattar
Abstract:: This dissertation describes the development of a new sustained release formulation of nifedipine. The new formulation was developed by coating commercially available immediate release soft elastic gelatin capsules using a spray coating technique with two different polymeric combinations. Dissolution studies were conducted and showed that controlled release of nifedipine was...
Resource Type:: Dissertation
Full Text:: Terbinafine after Single Oral Doses in Raptors. Abstract approved: J. Mark Christensen James W. A This

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Creator:: Ahmed, Iman Saad
Abstract:: This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
Resource Type:: Dissertation
Full Text:: myself privileged and honored to be one of his many graduate students. Dr. J. Mark Christensen for his

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

Creator:: Huang, Hua-pin
Abstract:: Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
Resource Type:: Dissertation
Full Text:: absorption process. That is, most of the "gut transport processes" in the above twenty-six compartment

Calcium alginate gels in oral dosage form design

Creator:: Lin, Shun Yih
Abstract:: In vivo research following ingesting of commercially available Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose of four tablets daily, showed serum lipoprotein concentrations did not change significantly. In order to increase the number of viable Lactobacillus bacteria after challenging in...
Resource Type:: Dissertation
Full Text:: ), and placebo tablets from April (A) to June (J); vice-versa for group 2. TC: total cholesterol; HDL

Prolonged duration of action of dyphylline through prodrugs

Creator:: Panomvana, Duangchit
Resource Type:: Dissertation
Full Text:: pleasure of having Dr. J. W. Ayres as my major professor. His friendliness, patience, encouragement

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Creator:: Watanalumlerd, Prapoch
Abstract:: Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
Resource Type:: Dissertation
Full Text:: learning. His kindness and understanding is much appreciated. I also thank Dr. J. Mark Christensen and Dr

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Creator:: Hossain, Mohammad
Abstract:: Gastrointestinal (GI) transit data were collected using pigs as animal models. Density and size effects of non-disintegrating dosage forms on GI transit were investigated. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate...
Resource Type:: Dissertation
Full Text:: greatly appreciate the valuable assistance of Barbara J. Watrous D.V.M. and Richard Kay of the College of

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: Fick's law of diffusion (34): J = -D dc/dx, where J is the flux of drug in amount/area-time, D is the

ScholarsArchive@OSU

Pharmacokinetic/pharmacodynamic modeling/simulation and novel gastric retention formulation

New acetaminophen products : formulation development and bioavailability

Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors

In vitro and in vivo testing of a gastric retention device : development and evaluation of a new colonic delivery system

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

Calcium alginate gels in oral dosage form design

Prolonged duration of action of dyphylline through prodrugs

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

New product formulations, pharmacokinetics and bioavailability of dyphylline

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