Index Catalog // ScholarsArchive@OSU

New product formulations and pharmacokinetics of acetaminophen

Creator:: Borin, Marie T.
Resource Type:: Dissertation
Full Text:: Acetaminophen AN ABSTRACT OF THE THESIS OF Marie T. Borin for the degree of Doctor of Philosophy in Pharmacy

Dissolution and bioavailability of immediate and sustained release cold and cough dosage forms

Creator:: Hsu, Huey-yuh
Abstract:: A high-pressure liquid chromatography method based on reported literature was developed for the quantitative analysis of chlorpheniramine, pseudoephedrine, phenylpropanolamine and acetaminophen in dissolution fluids and urine. The effects of buffer, pH and different concentrations of organic solvent in the mobile phase on chromatographic separation are described in Chapter I. Dissolution...
Resource Type:: Masters Thesis
Full Text:: ,,,/ i t 1 i i 1 ( 0 2 4 6 0 2 MINUTES 0 i 1 1 1 unit : cm b. c. 3 ..--. c o_ +-) L) a) 1 2

New acetaminophen products : formulation development and bioavailability

Creator:: Mansell, Libbie J.
Abstract:: Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
Resource Type:: Dissertation

Development and evaluation of an oral controlled release and a transdermal delivery system, for melatonin in human subjects

Creator:: Lee, Beom-jin
Resource Type:: Dissertation
Full Text:: :00 AM (t=0) in the morning. Asterisks show the time of TDD removal. VI.3 Cumulative amount of

Chelating agents in the drug dosage design of iron preparations

Creator:: Ghannam, Musa
Abstract:: The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
Resource Type:: Masters Thesis
Full Text:: ,/ \ // \ Fe CH N.Ae ..," \ qq---i, H H , rk......,.. z 2 / \ t N\ H H H H / H K = [II] [III] [/] [Fe+2

The absolute bioavailability of dyphylline tablets in human subjects

Creator:: Huston, Thomas K.
Abstract:: Dyphylline has been shown to be rapidly and completely absorbed from oral tablets in an absolute bioavailability study. In a pilot study two healthy male subjects received 1000 mg of dyphylline via intravenous infuson at a rate of 50 mg/min (1.0 ml/min) for 20 minutes. Plasma samples were collected for...
Resource Type:: Masters Thesis
Full Text:: area under the curve values after intravenous infusion via paired t-test. The paired t-test statistic

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: which diffusion occurs through channels: Q= [DE /T(2A -E Cs)CstJl /2 where Q is the amount of drug

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

Creator:: Hossain, Mohammad
Abstract:: Gastrointestinal (GI) transit data were collected using pigs as animal models. Density and size effects of non-disintegrating dosage forms on GI transit were investigated. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate...
Resource Type:: Dissertation
Full Text:: , particulate substance. Gastroenterology 89(2), 307-312 (1985). 11. Itoh T., Higuchi T., Gardner C.R., and

New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation

Tablet shapes and in vitro evaluation of coated hydrophilic matrix tablets novel mupirocin formulations non-acidic enteric coating of omeprazole and novel hot-melt coating process

Creator:: Leung, Manshiu
Abstract:: This dissertation is comprised of four distinct formulation sections, which are described below: A novel solid dosage formulation was investigated for achieving zero-order drug release profile by combining tablet shape design and tablet membrane film coating. Verapmail (model drug) was compressed into hydrophilic matrix tablet cores of flat-faced and bi-convex...
Resource Type:: Dissertation

ScholarsArchive@OSU

New product formulations and pharmacokinetics of acetaminophen

Dissolution and bioavailability of immediate and sustained release cold and cough dosage forms

New acetaminophen products : formulation development and bioavailability

Development and evaluation of an oral controlled release and a transdermal delivery system, for melatonin in human subjects

Chelating agents in the drug dosage design of iron preparations

The absolute bioavailability of dyphylline tablets in human subjects

New product formulations, pharmacokinetics and bioavailability of dyphylline

Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation

New product formulation and multiple dose pharmacokinetics of acetaminophen

Tablet shapes and in vitro evaluation of coated hydrophilic matrix tablets novel mupirocin formulations non-acidic enteric coating of omeprazole and novel hot-melt coating process

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search