Index Catalog // ScholarsArchive@OSU

Pharmacokinetic modeling of theophylline and dyphylline and pharmacodynamics of ibuprofen input rate on antipyresis

Creator:: Stevens, Ruth E.
Abstract:: Pharmacokinetic parameters for theophylline and dyphylline were evaluated in horse cerebrospinal fluid (csf) and plasma. Pharmacokinetic parameters did not differ significantly (p > 0.05) at the same dose for either drug when administered alone or concomitantly. Theophylline and dyphylline penetrate horse csf to produce approximately 1/2 the concentrations found in...
Resource Type:: Dissertation
Full Text:: and pharmacodynamics of ibuprofen input rate on antipyresis AN ABSTRACT OF THE THESIS OF Ruth E

Formulation and in vitro-in vivo evaluation of a new compression-coated tablet of amoxicillin/clavulanate and formulation potential of the antimicrobial peptide nisin

Creator:: Bani Jaber, Ahmad Kh.
Abstract:: This thesis is compromised of two distinct formulation sections, which are described below: New compression-coated tablet formulations were developed for amoxicillin/clavulanate. Amoxicillin in an outer coat was separated from clavulanic acid in a core tablet by inactive ingredients in a middle coat. A chewable compression-coated tablet formulation with 50% stearic...
Resource Type:: Dissertation
Full Text:: press (Fred S. Carver Inc., Summit, New Jersey). 2. Precompressed core and middle layer About half

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Creator:: Rakkanka, Vipaporn
Abstract:: This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...
Resource Type:: Dissertation
Full Text:: formulation E beads after compaction and crushing .................................................. 37 1.9

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: which diffusion occurs through channels: Q= [DE /T(2A -E Cs)CstJl /2 where Q is the amount of drug

Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

Creator:: Lorskulsint, Duangchit
Abstract:: The effect of concentration, vehicle and surfactant on the absorption of benzocaine -³H across the rat's rectal mucosa was investigated. Blood radioactivity levels were determined after the application of benzociane -³H containing suppositories and ointments. A wet oxidation method was used for sample digestion. Since the radioactivity counted is the...
Resource Type:: Masters Thesis
Full Text:: and sunburn rem- edies, and some solid preparations, i. e., troches or lozenges. Benzocaine is also

Assay and pharmacokinetics of dyphylline following oral administration in humans

Creator:: Gisclon, Lee Gehl
Abstract:: Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
Resource Type:: Masters Thesis
Full Text:: ., Sellersville, PA. A. B. F C E. TIME (MINUTES) TIME (MINUTES) 10 IO TIME (MINUTES) F. G. D 0 10

Evaluation of polycarbophil coated liposomes and membrane permeation of free and liposomal drugs

Creator:: Sorasuchart, Waranush
Resource Type:: Dissertation
Full Text:: 2 hours and then in intestinal fluid (pH 7.4) 64 III. 8-a-e Correlation of percentages of drug

Development and in vivo testing of a gastric retention device (GRD) in dogs

Creator:: Kapsi, Shivakumar G.
Abstract:: This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
Resource Type:: Dissertation
Full Text:: hydration in water of XG/LBG films at various solids ratios 3.0 2.5 2.0 = 1.5 1.0 a) 0.5 .F-: E 0.0

Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors

Creator:: Fahmy, Sahar Abd El-Sattar
Abstract:: This dissertation describes the development of a new sustained release formulation of nifedipine. The new formulation was developed by coating commercially available immediate release soft elastic gelatin capsules using a spray coating technique with two different polymeric combinations. Dissolution studies were conducted and showed that controlled release of nifedipine was...
Resource Type:: Dissertation
Full Text:: for 22 hours ............................................. 89 1.21 e Mean nifedipine release over 24

Product formulations and in vitro-in vivo evaluation of a novel "Tablet-in-a-Bottle" suspension formulation of amoxicillin and clavulanic acid

Creator:: Yang, Ning-Ning
Abstract:: This thesis describes a novel "Tablet-in-a-Bottle" oral suspension formulation. Ingredients with unstable physical or chemical characteristics can be placed in a core tablet, and then dry compression coated with an outer layer which provides separation from other components. The new suspension formulation comprises fast disintegrating clavulanic acid (KCA) tablets with...
Resource Type:: Masters Thesis
Full Text:: , Inc.), Methanol (Chromatographic grade, E. Merck, Darmstadt, Germany), Augmentin® 125 mg/5 ml oral

ScholarsArchive@OSU

Pharmacokinetic modeling of theophylline and dyphylline and pharmacodynamics of ibuprofen input rate on antipyresis

Formulation and in vitro-in vivo evaluation of a new compression-coated tablet of amoxicillin/clavulanate and formulation potential of the antimicrobial peptide nisin

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

New product formulations, pharmacokinetics and bioavailability of dyphylline

Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

Assay and pharmacokinetics of dyphylline following oral administration in humans

Evaluation of polycarbophil coated liposomes and membrane permeation of free and liposomal drugs

Development and in vivo testing of a gastric retention device (GRD) in dogs

Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors

Product formulations and in vitro-in vivo evaluation of a novel "Tablet-in-a-Bottle" suspension formulation of amoxicillin and clavulanic acid

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