Index Catalog // ScholarsArchive@OSU

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Creator:: Rakkanka, Vipaporn
Abstract:: This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...
Resource Type:: Dissertation
Full Text:: Oral Formulations, (3) A Novel Zero Order Release Matrix Tablet. Abstract approved James W This

Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

Creator:: Lorskulsint, Duangchit
Abstract:: The effect of concentration, vehicle and surfactant on the absorption of benzocaine -³H across the rat's rectal mucosa was investigated. Blood radioactivity levels were determined after the application of benzociane -³H containing suppositories and ointments. A wet oxidation method was used for sample digestion. Since the radioactivity counted is the...
Resource Type:: Masters Thesis
Full Text:: Duangchit Lorskulsint ACKNOWLEDGMENT I would like to express my deepest gratitude to Dr. J. W. Ayres for

Antimicrobial vaginal dosage forms employing Dimethyl Fumarate or propionic acid

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Propionic acid, live Propionibacterium shermanii, and Dimethyl Fumarate (DMF) were tested for their stimulatory or inhibitory efects on yeast, bacteria, and molds. The amount of propionic acid required for inhibition of molds was strain specific and equal to or less than that required for inhibition of the yeasts. Live P....
Resource Type:: Masters Thesis

Assay and pharmacokinetics of dyphylline following oral administration in humans

Creator:: Gisclon, Lee Gehl
Abstract:: Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
Resource Type:: Masters Thesis
Full Text:: ORAL ADMINISTRATION IN HUMANS Abstract approved: Redacted for privacy James W. Ayr4s(e7.D. Improved

Bioadhesive polymers in drug product formulations

Creator:: Tavipatana, Wattanaporn
Abstract:: Gastric retention time of single unit dosage forms in swine was found to be much longer than in humans. It was concluded that swine are not a good animal model to study GI transit time of nonerodable or slowly eroded dosage forms. Noneradable and slowly eroded dosage forms used to...
Resource Type:: Dissertation
Full Text:: approved: _Redacted for Privacy ((/ James W. Ayres, Ph /. / Gastric retention time of single unit dosage

Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits

Creator:: Mayo, Charles Edward
Abstract:: The bioavailability and pharmacokinetics of theophylline in rabbits were determined following both oral and intravenous administration of the drug. Serum theophylline concentrations were determined using high pressure liquid chromatography. Pharmacokinetic parameters were determined and verified by computer analysis. The overall mean Beta disposition constant was 0.089 hr⁻¹ which corresponds to...
Resource Type:: Masters Thesis
Full Text:: DYPHYLLINE AND THEOPHYLLINE IN RABBITS Abstract approved: Redacted for Privacy Dr. James W. Ayres V Part

Bioequivalence studies of ketoprofen : product formulation, pharmacokinetics, deconvolution, and in vitro - in vivo correlations

Creator:: Holt, Kris Edward
Abstract:: This thesis describes a project to produce controlled release ketoprofen beads for capsules, both at Oregon State University and in an industrial scale-up operation, that are bioequivalent to the commercial product Oruvail. A bead formulation was produced by layering drug and binders in water onto nonpareil sugar seeds in a...
Resource Type:: Dissertation
Full Text:: standard. 3 CHAPTER 1 DECONVOLUTION IN SUSTAINED-RELEASE FORMULATION by Kris E. Holt and James W

Calcium alginate gels in oral dosage form design

Creator:: Lin, Shun Yih
Abstract:: In vivo research following ingesting of commercially available Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose of four tablets daily, showed serum lipoprotein concentrations did not change significantly. In order to increase the number of viable Lactobacillus bacteria after challenging in...
Resource Type:: Dissertation
Full Text:: for Privacy James W. Ayres, Ph.D. In vivo research following ingesting of commercially available

Chelating agents in the drug dosage design of iron preparations

Creator:: Ghannam, Musa
Abstract:: The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
Resource Type:: Masters Thesis
Full Text:: ACKNOWLEDGMENTS I would like to express my deepest appreciation to Dr. J. W. Ayres who was an excellent advisor

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Creator:: Mohamed, Osama H.
Abstract:: This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Resource Type:: Dissertation

ScholarsArchive@OSU

A novel self-sealing chewable sustained release tablet of acetaminophen ; Development and evaluation of novel itraconazole oral formulations ; A novel zero order release matrix tablet

Absorption of benzocaine -³H from semi-solid dosage forms following rectal administration in rats

Antimicrobial vaginal dosage forms employing Dimethyl Fumarate or propionic acid

Assay and pharmacokinetics of dyphylline following oral administration in humans

Bioadhesive polymers in drug product formulations

Bioavailability and pharmacokinetics of dyphylline and theophylline in rabbits

Bioequivalence studies of ketoprofen : product formulation, pharmacokinetics, deconvolution, and in vitro - in vivo correlations

Calcium alginate gels in oral dosage form design

Chelating agents in the drug dosage design of iron preparations

Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search