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Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation
Full Text:: ) Weight (Kg) Max Dose (mg/kg) 1 F 22 59.00 16.95 2 M 25 55.00 18.18 3 M 27 68.18 14.67 4 M 25 62.00

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation

Creator:: Borin, Marie T.
Resource Type:: Dissertation
Full Text:: analysis using a delivery pump (M-6000A, Waters Associates, Milford, MA), automatic sample injector (WISP

Creator:: Konsil, Julraht
Resource Type:: Dissertation
Full Text:: Konsil presented on June 9, 1997. APPROVED: Co-M Co-Major Professor, representing Pharmacy Dean of

Creator:: Fahmy, Sahar Abd El-Sattar
Abstract:: This dissertation describes the development of a new sustained release formulation of nifedipine. The new formulation was developed by coating commercially available immediate release soft elastic gelatin capsules using a spray coating technique with two different polymeric combinations. Dissolution studies were conducted and showed that controlled release of nifedipine was...
Resource Type:: Dissertation

Creator:: Watanalumlerd, Prapoch
Abstract:: Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
Resource Type:: Dissertation
Full Text:: ) clearly showed double-pulsed release of the drug from the formulation (16). DEXTROAMPHETAMINE O-- M

Creator:: Mohamed, Osama H.
Abstract:: This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Resource Type:: Dissertation
Full Text:: , Joanne, Greta, Mick and Karl. Last but not least, I would like to thank Angela Lacey from Portland VA

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