Index Catalog // ScholarsArchive@OSU

Development and in vivo testing of a gastric retention device (GRD) in dogs

Creator:: Kapsi, Shivakumar G.
Abstract:: This thesis describes 1) development of a gastric retention device (GRD) to increase gastric retention time of certain drugs, 2) product formulations of an immediate release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked carbohydrate polymers. Rate and extent of hydration of the film in water and in simulated...
Resource Type:: Dissertation
Full Text:: Evaluation of, a) Immediate Release Formulation of Itraconazole, b) Controlled-Release Formulation of

Tablet shapes and in vitro evaluation of coated hydrophilic matrix tablets novel mupirocin formulations non-acidic enteric coating of omeprazole and novel hot-melt coating process

Creator:: Leung, Manshiu
Abstract:: This dissertation is comprised of four distinct formulation sections, which are described below: A novel solid dosage formulation was investigated for achieving zero-order drug release profile by combining tablet shape design and tablet membrane film coating. Verapmail (model drug) was compressed into hydrophilic matrix tablet cores of flat-faced and bi-convex...
Resource Type:: Dissertation
Full Text:: Omeprazole; and Novel Hot-Melt Coating Process. Abstract approved: James W This dissertation is comprised

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: , Tp, and MAT for formulations A, B, and C. Dyphylline may be effective when given by the inhalation

Development of Hot-melt Pan-coating, Application to Sustained-release Capsules and Tamper Resistant-coating. 2) Formulation of Verapamil HCl and Diltiazem HCl Semisolid Matrix Capsules. 3) Novel Sustained Release Tablet of Glipizide: Compression of Coated Drug Beads, Formulation, Dissolution, and Convolution. 4) Verapamil Sustained Release: New Formulation and Convolution

Creator:: Nguyen, Chien Ngoc
Abstract:: Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating...
Resource Type:: Dissertation
Full Text:: approved: James W. Ayres J. Mark Christensen Hot-melt pan-coating, which is a novel

Preparing sustained release dosage forms of nifedipine by hot-melt coating method

Creator:: Le, Hang Thi
Abstract:: A nifedipine sustained release dosage form was prepared by using hot-melt batch coating. Substrates are sugar beads, mesh size 30-35. Stearic acid, Acid Triglyceride, and carnauba wax were coating agents used to make single layer coated beads and multiple layer coated beads containing nifedipine. Dissolution of nifedipine from the beads...
Resource Type:: Masters Thesis
Full Text:: Nifedipine by Hot-melt Coating Method Abstract J. Mark Christensen (I James W Ayres A nifedipine

Dissolution and bioavailability of immediate and sustained release cold and cough dosage forms

Creator:: Hsu, Huey-yuh
Abstract:: A high-pressure liquid chromatography method based on reported literature was developed for the quantitative analysis of chlorpheniramine, pseudoephedrine, phenylpropanolamine and acetaminophen in dissolution fluids and urine. The effects of buffer, pH and different concentrations of organic solvent in the mobile phase on chromatographic separation are described in Chapter I. Dissolution...
Resource Type:: Masters Thesis
Full Text:: Results and Discussion 91 Conclusions 111 References 113 Bibliography 115 Appendix A 117 Appendix B 160

Product formulations and in vitro-in vivo evaluation of a novel "Tablet-in-a-Bottle" suspension formulation of amoxicillin and clavulanic acid

Creator:: Yang, Ning-Ning
Abstract:: This thesis describes a novel "Tablet-in-a-Bottle" oral suspension formulation. Ingredients with unstable physical or chemical characteristics can be placed in a core tablet, and then dry compression coated with an outer layer which provides separation from other components. The new suspension formulation comprises fast disintegrating clavulanic acid (KCA) tablets with...
Resource Type:: Masters Thesis
Full Text:: . CONTRIBUTION OF AUTHORS Dr. James Ayres was involved in the formulation design, data interpretation, and

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

Creator:: Anderson, John L.
Resource Type:: Masters Thesis
Full Text:: during treatment A (control) are greater than during treatment B but only 2 of 10 of the differences

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Creator:: Olson, Stephen Carl
Abstract:: The relative bioavailability and pharmacodynamics of tolbutamide from two different commercially available tablet products has been evaluated in healthy subjects in a single dose cross over study. Products were aged by exposing tablets to 98% relative humidity for 3 days at ambient temperature which was found to differentially affect both...
Resource Type:: Dissertation
Full Text:: PRODUCTS Abstract Approved: Redacted for Privacy James W. Ayres, PhiDO The relative bioavailability and

Formulation studies of lactic acid-producing bacteria for oral administration

Creator:: Liou, Yow-Hwa Grace
Abstract:: Effects of lactobacilli in enteric coated capsules were studied in piglets (Chapter I). Lactobacillus acidophilus and Lactobacillus bulgaricus isolated from a commercial product were formulated in capsules, enteric coated, and then given to both Escherichia coli-challenged and unchallenged baby pigs. Decreased incidence and severity of diarrhea, and decreased weight deceleration...
Resource Type:: Dissertation
Full Text:: Bacteria for Oral Administration Redacted for Privacy Abstract approved: Dr. Jame$ fq1. Ayres Effects of

ScholarsArchive@OSU

Development and in vivo testing of a gastric retention device (GRD) in dogs

Tablet shapes and in vitro evaluation of coated hydrophilic matrix tablets novel mupirocin formulations non-acidic enteric coating of omeprazole and novel hot-melt coating process

New product formulations, pharmacokinetics and bioavailability of dyphylline

Preparing sustained release dosage forms of nifedipine by hot-melt coating method

Dissolution and bioavailability of immediate and sustained release cold and cough dosage forms

Product formulations and in vitro-in vivo evaluation of a novel "Tablet-in-a-Bottle" suspension formulation of amoxicillin and clavulanic acid

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Formulation studies of lactic acid-producing bacteria for oral administration

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