This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
In vivo research following ingesting of commercially available
Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of
Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose
of four tablets daily, showed serum lipoprotein concentrations did not
change significantly. In order to increase the number of viable
Lactobacillus bacteria after challenging in...
Dyphylline is an analogue of theophylline and the
latter is the most popular member of the methyixanthine
family in use for the treatment of asthma. Although
dyphylline is devoid of some problems associated with
theophylline, a reported short half-life for dyphylline
(2.1 hours) has made its clinical usefulness limited. In...
This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...
This thesis describes 1) development of a gastric retention device (GRD) to
increase gastric retention time of certain drugs, 2) product formulations of an immediate
release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked
carbohydrate polymers. Rate and extent of hydration of the film in water and in
simulated...