Index Catalog // ScholarsArchive@OSU

Pharmacokinetic/pharmacodynamic modeling/simulation and novel gastric retention formulation

Creator:: Kwon, Hyojong
Abstract:: This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
Resource Type:: Dissertation
Full Text:: /PHARMACODYNAMIC MODELING/SIMULATION AND NOVEL GASTRIC RETENTION FORMULATION. Abstract approved: James W. Ayres

New acetaminophen products : formulation development and bioavailability

Creator:: Mansell, Libbie J.
Abstract:: Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
Resource Type:: Dissertation
Full Text:: bioavailability AN ABSTRACT OF THE THESIS OF Libbie J. Mansell for the degree of Doctor of Philosophy in

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Creator:: Farid, Samar Farghali
Abstract:: This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...
Resource Type:: Dissertation
Full Text:: Hypertensive Patients. Abstract Approved: James W This thesis describes in vitro and in vivo evaluation of a

Formulation and pharmacokinetics of melatonin

Creator:: Konsil, Julraht
Resource Type:: Dissertation
Full Text:: . I would like to thank my two major professors; Dr. Keith A. Parrott and Dr. James W. Ayres, for

Evaluation of polycarbophil coated liposomes and membrane permeation of free and liposomal drugs

Creator:: Sorasuchart, Waranush
Resource Type:: Dissertation
Full Text:: Nicardipine HCl Sustained-Release Formulations. J. Mark Christensen Abst act approved: James W. Ayres An

Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors

Creator:: Fahmy, Sahar Abd El-Sattar
Abstract:: This dissertation describes the development of a new sustained release formulation of nifedipine. The new formulation was developed by coating commercially available immediate release soft elastic gelatin capsules using a spray coating technique with two different polymeric combinations. Dissolution studies were conducted and showed that controlled release of nifedipine was...
Resource Type:: Dissertation
Full Text:: Terbinafine after Single Oral Doses in Raptors. Abstract approved: J. Mark Christensen James W. A This

Preparing sustained release dosage forms of nifedipine by hot-melt coating method

Creator:: Le, Hang Thi
Abstract:: A nifedipine sustained release dosage form was prepared by using hot-melt batch coating. Substrates are sugar beads, mesh size 30-35. Stearic acid, Acid Triglyceride, and carnauba wax were coating agents used to make single layer coated beads and multiple layer coated beads containing nifedipine. Dissolution of nifedipine from the beads...
Resource Type:: Masters Thesis
Full Text:: Nifedipine by Hot-melt Coating Method Abstract J. Mark Christensen (I James W Ayres A nifedipine

Development and evaluation of a sustained release amoxicillin dosage form

Creator:: Ge, Yan, 1962-
Resource Type:: Masters Thesis
Full Text:: . James W. Ayres. Who was the instructor of my first class I took in the US. That class gave me the

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: Fick's law of diffusion (34): J = -D dc/dx, where J is the flux of drug in amount/area-time, D is the

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

Creator:: Huang, Hua-pin
Abstract:: Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
Resource Type:: Dissertation
Full Text:: . Maney, J. W. Jones, E. G. Gross and H. M. Korns, J. Am. Pharm. Assoc. 35, 266 (1946). 3. J. D. McColl

ScholarsArchive@OSU

Pharmacokinetic/pharmacodynamic modeling/simulation and novel gastric retention formulation

New acetaminophen products : formulation development and bioavailability

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Formulation and pharmacokinetics of melatonin

Evaluation of polycarbophil coated liposomes and membrane permeation of free and liposomal drugs

Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors

Preparing sustained release dosage forms of nifedipine by hot-melt coating method

Development and evaluation of a sustained release amoxicillin dosage form

New product formulations, pharmacokinetics and bioavailability of dyphylline

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

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