Index Catalog // ScholarsArchive@OSU

Assay and pharmacokinetics of dyphylline following oral administration in humans

Creator:: Gisclon, Lee Gehl
Abstract:: Improved assay methods for determination of dyphylline levels in plasma, saliva, and urine utilizing high pressure liquid chromatography have been developed. Detection of levels as low as 25 ng/ml from 0.5 ml plasma and 50 ng/ml from 0.5 ml saliva were possible. Both procedures utilized the same extraction process. A...
Resource Type:: Masters Thesis
Full Text:: between saliva and plasma dyphylline concentrations of individuals using parabolic equations, the r 2

The absolute bioavailability of dyphylline tablets in human subjects

Creator:: Huston, Thomas K.
Abstract:: Dyphylline has been shown to be rapidly and completely absorbed from oral tablets in an absolute bioavailability study. In a pilot study two healthy male subjects received 1000 mg of dyphylline via intravenous infuson at a rate of 50 mg/min (1.0 ml/min) for 20 minutes. Plasma samples were collected for...
Resource Type:: Masters Thesis
Full Text:: regression for this time (1-12 hr) are -0.2592 for subject one (r = 0.9976) and -0.3899 for subject two (r

New product formulations, pharmacokinetics and bioavailability of dyphylline

Creator:: Chang, Shyi-Feu
Abstract:: Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage forms are presented in chapter one of this thesis. In vivo single dose and multiple dose studies of two sustained-release formulations as well as one conventional dyphylline formulation are described in chapter two. The pharmacokinetics of dyphylline following...
Resource Type:: Dissertation
Full Text:: /tablet)) in pigs 1, 2, and 3; data were derived by Wagner-Nelson method 11.6 Percent dyphylline

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

Creator:: Huang, Hua-pin
Abstract:: Dyphylline is an analogue of theophylline and the latter is the most popular member of the methyixanthine family in use for the treatment of asthma. Although dyphylline is devoid of some problems associated with theophylline, a reported short half-life for dyphylline (2.1 hours) has made its clinical usefulness limited. In...
Resource Type:: Dissertation
Full Text:: function to the stomach C s Prodrug concentration in the stomach R s : Prodrug mass transport rate

Formulation and pharmacokinetics of melatonin

Creator:: Konsil, Julraht
Resource Type:: Dissertation
Full Text:: Table LIST OF TABLES (continued) Page 6.2 Flux (R/hr/cm2), permeability coefficient (cm/hr), and lag

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

Creator:: Anderson, John L.
Resource Type:: Masters Thesis
Full Text:: Investigation of a Potential Drug Interaction: Aminophylline and Prednisone by John L. Anderson R. Ph. A

New product formulations and pharmacokinetics of acetaminophen

Creator:: Borin, Marie T.
Resource Type:: Dissertation
Full Text:: plasma concentrations of 10 to 20 pg/ml (Wagner, 1975) but is 15 to 21% bound at a plasma concentration

New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation
Full Text:: at usual therapeutic concentrations (Wagner 1975) as binding does not occur with plasma

Preformulation studies for oral dosage forms of lactobacilli

Creator:: Liou, Grace Yow-Hwa
Abstract:: Lactobacilli have been used in the dairy and pharmaceutical industries because of their nutritious and/or therapeutic effects. Lactobacillus acidophilus and Lactobacillus bulqaricus were isolated from a commercially available product and studied for their growth and colony characteristics as described in Chapter I and Chapter II. Survival of these lactobacilli in...
Resource Type:: Masters Thesis
Full Text:: June 1985 APPROVED: Redacted for Privacy Prof es r of Pharmacy in Challelef Major Redacted for

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Creator:: Farid, Samar Farghali
Abstract:: This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...
Resource Type:: Dissertation

ScholarsArchive@OSU

Assay and pharmacokinetics of dyphylline following oral administration in humans

The absolute bioavailability of dyphylline tablets in human subjects

New product formulations, pharmacokinetics and bioavailability of dyphylline

Pharmacokinetics of dyphylline after administration of prodrugs in rabbits and pigs

Formulation and pharmacokinetics of melatonin

Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

New product formulations and pharmacokinetics of acetaminophen

New product formulation and multiple dose pharmacokinetics of acetaminophen

Preformulation studies for oral dosage forms of lactobacilli

Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patients

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search