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Filtering by: Creator Zajicek, James L. Remove constraint Creator: Zajicek, James L. Advisor Ayres, James W. Remove constraint Advisor: Ayres, James W.

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  • Pharmacokinetic investigation of a potential drug interaction : aminophylline and prednisone

    Creator:
    Anderson, John L.
    Resource Type:
    Masters Thesis
    Full Text:
    interaction : aminophylline and prednisone AN ABSTRACT OF THE THESIS OF John L. Anderson for the degree of

  • The study of pharmacokinetics in a clinical environment

    Creator:
    Tse, Sunny
    Abstract:
    This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
    Resource Type:
    Dissertation
    Full Text:
    . Abstract approved: James W. Ayres This dissertation presents a research series

  • New acetaminophen products : formulation development and bioavailability

    Creator:
    Mansell, Libbie J.
    Abstract:
    Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
    Resource Type:
    Dissertation
    Full Text:
    Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores

  • Preformulation studies with 1, 3-bis (2-chloroethyl)-1-nitrosourea (NSC 409962)

    Creator:
    Laskar, Paul A.
    Abstract:
    The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was investigated in several buffered aqueous media, in mixed solvent and in nonaqueous solvent systems, and in the presence of several electrolytes and nonelectrolytes. The degradation rate constant of BCNU in these systems was calculated from the parameters of the linear regression of...
    Resource Type:
    Dissertation
    Full Text:
    privacy Dr. James W. All The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962)(BCNU) was

  • Preformulation studies for oral dosage forms of lactobacilli

    Creator:
    Liou, Grace Yow-Hwa
    Abstract:
    Lactobacilli have been used in the dairy and pharmaceutical industries because of their nutritious and/or therapeutic effects. Lactobacillus acidophilus and Lactobacillus bulqaricus were isolated from a commercially available product and studied for their growth and colony characteristics as described in Chapter I and Chapter II. Survival of these lactobacilli in...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: Redacted for Privacy )N Dr. James W. Oers ABSTRACT Lactobacilli have been used in the

  • Pharmacokinetics of theophylline and it's N-7 derivatives in rabbits

    Creator:
    Tavipatana, Wattanaporn
    Abstract:
    Pharmacokinetics of theophylline and N-7 substituted theophylline in rabbits when administered alone and in various combinations were investigated. This thesis has four chapters dealing with etophylline and theophylline; proxyphylline and theophylline; dyphylline and theophylline; and etophylline, proxyphylline and dyphylline pharmacokinetics when administered concomitantly. All chapters are interrelated. Each chapter has...
    Resource Type:
    Masters Thesis
    Full Text:
    0.704 L/kg respectively. Plasma con- centration data for bolus etophylline were fitted by a two

  • Formulation studies of lactic acid-producing bacteria for oral administration

    Creator:
    Liou, Yow-Hwa Grace
    Abstract:
    Effects of lactobacilli in enteric coated capsules were studied in piglets (Chapter I). Lactobacillus acidophilus and Lactobacillus bulgaricus isolated from a commercial product were formulated in capsules, enteric coated, and then given to both Escherichia coli-challenged and unchallenged baby pigs. Decreased incidence and severity of diarrhea, and decreased weight deceleration...
    Resource Type:
    Dissertation
    Full Text:
    Bacteria for Oral Administration Redacted for Privacy Abstract approved: Dr. Jame$ fq1. Ayres Effects of

  • Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

    Creator:
    Watanalumlerd, Prapoch
    Abstract:
    Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
    Resource Type:
    Dissertation
    Full Text:
    Formulations 3) Development of Leaky Enteric-Coated Pellets Formulations Abstract James W. Effects of

  • Calcium alginate gels in oral dosage form design

    Creator:
    Lin, Shun Yih
    Abstract:
    In vivo research following ingesting of commercially available Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose of four tablets daily, showed serum lipoprotein concentrations did not change significantly. In order to increase the number of viable Lactobacillus bacteria after challenging in...
    Resource Type:
    Dissertation
    Full Text:
    for Privacy James W. Ayres, Ph.D. In vivo research following ingesting of commercially available

  • Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations

    Creator:
    Mohamed, Osama H.
    Abstract:
    This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
    Resource Type:
    Dissertation
    Full Text:
    and the enormous feeling of gratefulness for Dr. James Ayres who is my major professor and my advisor