Index Catalog // ScholarsArchive@OSU

Creator:: Mangold, Kathy A.
Abstract:: The rainbow trout (Oncorhynchus mykiss) model of chemical carcinogenesis is becoming increasingly important as a supplement to rodent studies. However, much of the molecular biology of the carcinogenic response is still unknown in the trout model. The ras gene family has been implicated in the tumorigenesis of both spontaneous and...
Resource Type:: Dissertation
Full Text:: Characterization of a ras gene in rainbow trout AN

Creator:: Chang, Yung-jin
Abstract:: For ras gene mutation analysis in the rainbow trout (Oncorhynchus mykiss) model system, a partial trout ras sequence was identified using the polymerase chain reaction (PCR). Two synthetic oligonucleotides based on rat K-ras gene sequence were used as primers for the PCR procedure. A 90 base pair (bp) sequence, referred...
Resource Type:: Dissertation
Full Text:: Analysis of ras gene mutations in rainbow trout tumors

Creator:: Pratt, Mary Margaret
Abstract:: Chlorophyllin (CHL), a water-soluble derivative of the green plant pigment, chlorophyll, is an effective antimutagen and anticarcinogen in various model systems when used as a modulator against a class of carcinogens that, in general, have a structure consisting of at least three fused rings. Dibenzo[a,l]pyrene (DBP), an extremely potent environmental...
Resource Type:: Dissertation
Full Text:: Chemoprevention Against Dibenzo[a,/]pyrene-Initiated Multi-organ Carcinogenesis in the Rainbow Trout Model

Creator:: Swanson, Hollie I.
Abstract:: Indole-3-carbinol (I3C) inhibits chemically induced tumor formation in rodents and rainbow trout. This study examines the effect of I3C and its analog, indole-3-acetonitrile (I3N) on xenobiotic-metabolizing enzyme systems. The modulation of these enzyme systems have been shown to have significant effects on the interaction of chemical carcinogens and cellular constituents....
Resource Type:: Masters Thesis
Full Text:: : Effects of the Anticarcinogen Indole-3-carbinol on Xenobiotic Metabolizing Enzymes in the Rainbow Trout

Creator:: Van Winkle, Samina
Abstract:: Dimethylbenz (a) anthracene (EMBA), a carcinogen that requires metabolic activation to produce active metabolites capable of binding to DNA, has been studied in the trout and other fish. Polycyclic aromatic hydrocarbons (PAH) are of importance as they are ubiquitous in the environment and their carcinogenic effects in fish from contaminated...
Resource Type:: Masters Thesis
Full Text:: ; Diethylnitrosamine. Ethylnitrosourea. And nimprhhylbenz (a) anthracene CMA Binding Studies In The Rainbow Trout

Creator:: Ford, Bryan L.
Abstract:: Previous work (Thorgaard, G. H. et al., Aquatic Toxicology 46:121-126, 1999) showed triploid rainbow trout (0. mykiss) given embryonic carcinogen bath exposures had significant reduction of induced tumors relative to diploids. In the present study, trout were made triploid by thermal shock after fertilization. At age of 5 months they...
Resource Type:: Dissertation

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