Index Catalog // ScholarsArchive@OSU

Creator:: Mangold, Kathy A.
Abstract:: The rainbow trout (Oncorhynchus mykiss) model of chemical carcinogenesis is becoming increasingly important as a supplement to rodent studies. However, much of the molecular biology of the carcinogenic response is still unknown in the trout model. The ras gene family has been implicated in the tumorigenesis of both spontaneous and...
Resource Type:: Dissertation
Full Text:: : Redacted for Privacy C1 George S. Bailey, Major Professor The rainbow trout (Oncorhynchus mykiss) model

Creator:: Chang, Yung-jin
Abstract:: For ras gene mutation analysis in the rainbow trout (Oncorhynchus mykiss) model system, a partial trout ras sequence was identified using the polymerase chain reaction (PCR). Two synthetic oligonucleotides based on rat K-ras gene sequence were used as primers for the PCR procedure. A 90 base pair (bp) sequence, referred...
Resource Type:: Dissertation
Full Text:: Tumors. Abstract approved : Redacted for Privacy George S. Bailey For ras gene mutation analysis in

Creator:: Cheng, Ronshan
Abstract:: A digoxigenin-labeled nonradioactive detection system was used to screen a zebrafish cDNA library for p53-like and ras-like genes. One clone was isolated and identified as an incomplete p53-like gene. The insert size of this clone is 1777 bp, which encodes part of evolutionarily conserved region II and all of regions...
Resource Type:: Dissertation
Full Text:: Suppressor Genes in Fish Carcinogenesis Models. Abstract approved: ^ .. 4 j> George S. Bailey

Creator:: Swanson, Hollie I.
Abstract:: Indole-3-carbinol (I3C) inhibits chemically induced tumor formation in rodents and rainbow trout. This study examines the effect of I3C and its analog, indole-3-acetonitrile (I3N) on xenobiotic-metabolizing enzyme systems. The modulation of these enzyme systems have been shown to have significant effects on the interaction of chemical carcinogens and cellular constituents....
Resource Type:: Masters Thesis
Full Text:: Abstract approved: ft- ^^ ^ g/- — ' j — /George S. Bailey Indole-3-carbinol (I3C) inhibits chemically

Creator:: Van Winkle, Samina
Abstract:: Dimethylbenz (a) anthracene (EMBA), a carcinogen that requires metabolic activation to produce active metabolites capable of binding to DNA, has been studied in the trout and other fish. Polycyclic aromatic hydrocarbons (PAH) are of importance as they are ubiquitous in the environment and their carcinogenic effects in fish from contaminated...
Resource Type:: Masters Thesis
Full Text:: . Abstract approved: - - f George S. Bailey Dimethylbenz (a) anthracene (EMBA), a carcinogen that

Creator:: Valsta, Liisa M.
Abstract:: In rodent models as well as in fish models there are significant species differences in the susceptibility toward aflatoxin B₁ (AFB₁) carcinogenesis. Mouse is less susceptible toward AFB₁ carcinogenesis than rat. Researchers have come to the conclusion that the lower susceptibility of mice is not a result of less effective...
Resource Type:: Masters Thesis
Full Text:: very memorable. I would like to express my gratitude to my major professor, Dr. George Bailey, for

Creator:: Pratt, Mary Margaret
Abstract:: Chlorophyllin (CHL), a water-soluble derivative of the green plant pigment, chlorophyll, is an effective antimutagen and anticarcinogen in various model systems when used as a modulator against a class of carcinogens that, in general, have a structure consisting of at least three fused rings. Dibenzo[a,l]pyrene (DBP), an extremely potent environmental...
Resource Type:: Dissertation
Full Text:: Abstract approved by: George S. Bailey Chiorophyllin (CHL), a water-soluble derivative of the green plant

ScholarsArchive@OSU