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Filtering by: Creator Kuriyama, Y. Advisor Baird, William M.

Adapting computer science technologies to bridge critical gaps in proposed Tox21 risk assessment programs

Creator:

Larkin, Andrew

Abstract:

In 2004 the National Toxicology Program published an article describing their intent to pursue toxicology testing and risk assessment practices solely reliant on high throughput in vitro datasets and in silico modeling for dose-response assessments. Support and contributions form regulatory agencies and a significant portion of the life sciences community...

Resource Type:

Dissertation

Full Text:

hydrocarbon receptor (AhR) activation (Fujii-Kuriyama and Mimura, 2005; Lin et al., 2003). The AhR pathway
Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:

Courter, Lauren A.

Abstract:

Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...

Resource Type:

Dissertation

Full Text:

. Washington D.C.: American Chemical Society, 1985. 12. Wood, A. W., Levin, W., Lu, A. Y., Yagi, H
DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:

Hooven, Louisa Ada

Abstract:

Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...

Resource Type:

Dissertation