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Filtering by: Creator Amarasinghe, Upali S. Remove constraint Creator: Amarasinghe, Upali S. Advisor Barbar, Elisar J. Remove constraint Advisor: Barbar, Elisar J.

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  • Three Sites are Better than One : Exploring Multivalency in LC8 Binding Partners

    Creator:
    Clark, Sarah A.
    Abstract:
    Hub proteins bind a large number of partners to facilitate structural changes and downstream protein interactions. LC8, a highly conserved protein homodimer, is a unique hub that regulates the activity of proteins in a wide range of cellular processes by binding to intrinsically disordered regions. With many of these systems,...
    Resource Type:
    Dissertation
    Full Text:
    peptides clearly illustrate that LC8’s binding groove can only accommodate one peptide at a time8-10