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Filtering by: Creator Lipton, R. Remove constraint Creator: Lipton, R. Advisor Barofsky, Douglas F. Remove constraint Advisor: Barofsky, Douglas F.

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  • Proteomic analyses of marine bacteria

    Creator:
    Sowell, Sarah M.
    Abstract:
    Proteins are the metabolic machines of the cell and as such, the study of proteins could illuminate the dominant biological activities that are occurring within cells and reveal how an organism interacts with its environment. Here, we used proteomic techniques to study the abundant marine bacterium SAR11 both as an...
    Resource Type:
    Dissertation
    Full Text:
    Pacific Northwest National Laboratories consisting of Angela Norbeck, Mary Lipton, Carrie Nicora, and

  • Gas-phase fragmentation chemistry of protonated peptide ions

    Creator:
    Bythell, Benjamin James
    Abstract:
    The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...
    Resource Type:
    Dissertation
    Full Text:
    neutral R side chain. 120 3.1b b2-y1 amide bond cleavage for SB species with deprotonated C- terminus

  • Proteomic approach to the analysis of DNA-binding proteins using mass spectrometry

    Creator:
    Stapels, Martha Degen
    Abstract:
    In proteomic studies, separate experimental protocols have been necessary to identify proteins, determine their function, and predict their three-dimensional structure. In this study, a function-based separation of proteins was conceived to fractionate proteins prior to enzymatic digestion. In the initial demonstration of this technique, a DNA substrate was used to...
    Resource Type:
    Dissertation
    Full Text:
    Proteomics," Anal Chem, 73: 5683-5690. 5. Lipton, M.S., Pasa-Tolic, L., Anderson, G.A., Anderson, D.J