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Filtering by: Subject Nucleic acids -- Structure Advisor Barofsky, Douglas F.

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

Creator:

Jensen, Ole Norregaard

Abstract:

A novel protocol for the study of protein-nucleic acid interactions is presented and demonstrated to be feasible. The protocol combines photochemical crosslinking techniques and mass spectrometric methods into a new strategy for identifying protein domains or amino acid residues that are in close contact with nucleic acid in protein-nucleic acid...

Resource Type:

Dissertation

Full Text:

for non-specific protein-nucleic acid interactions. Let us first take a look at the structure of DNA