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Filtering by: Creator Ogawa Abe, Tania Marie Advisor Beckman, Joseph

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Creator:

Beilby, Pamela R.

Abstract:

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...

Resource Type:

Dissertation